Nucleoside analog: Difference between revisions
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===Serious=== | ===Serious=== | ||
*Neurotoxicity (e.g., cidofovir, tenofovir) | *Neurotoxicity (e.g., [[cidofovir]], [[tenofovir]]) | ||
*Nephrotoxicity (e.g., acyclovir in renal impairment) | *Nephrotoxicity (e.g., [[acyclovir]] in renal impairment) | ||
*Lactic acidosis and hepatotoxicity (e.g., nucleoside reverse transcriptase inhibitors like zidovudine) | *Lactic acidosis and hepatotoxicity (e.g., nucleoside reverse transcriptase inhibitors like [[zidovudine]]) | ||
*Bone density loss (e.g., tenofovir) | *Bone density loss (e.g., [[tenofovir]]) | ||
*Teratogenicity (e.g., ribavirin contraindicated in pregnancy) | *Teratogenicity (e.g., [[ribavirin]] contraindicated in pregnancy) | ||
==List of Nucleoside analoges== | |||
{{#ask:[[Is DrugClass::nucleoside analoge]] |format=ul }} | {{#ask:[[Is DrugClass::nucleoside analoge]] |format=ul }} | ||
[[Category:Pharmacology]] | [[Category:Pharmacology]] | ||
Revision as of 15:43, 30 August 2025
Mechanism of Action
- Nucleoside analoges are a class of antiviral medications that mimic the structure of natural nucleosides, interfering with viral DNA or RNA synthesis
- Primarily used for treatment of herpesvirus infections (e.g., HSV, VZV), HIV, hepatitis B and C, and some other viral infections
- Work by being incorporated into viral nucleic acids, leading to chain termination or mutagenesis
Adverse Effects
Common
- Nausea, vomiting, diarrhea
- Headache, fatigue
- Rash or pruritus
- Bone marrow suppression (e.g., zidovudine)
Serious
- Neurotoxicity (e.g., cidofovir, tenofovir)
- Nephrotoxicity (e.g., acyclovir in renal impairment)
- Lactic acidosis and hepatotoxicity (e.g., nucleoside reverse transcriptase inhibitors like zidovudine)
- Bone density loss (e.g., tenofovir)
- Teratogenicity (e.g., ribavirin contraindicated in pregnancy)