Meclizine: Difference between revisions
| Line 32: | Line 32: | ||
==Pharmacology== | ==Pharmacology== | ||
*Half-life: | *Onset: 1 hour | ||
*Metabolism: | *Half-life: 5 hours | ||
*Excretion: | *Metabolism: Hepatic | ||
*Mechanism of Action: | *Excretion: Urine and feces | ||
*Mechanism of Action: Central anticholinergic; blocks chemoreceptor trigger zone. Decreases middle ear excitability, blocks vestibular-cerebellar pathways | |||
==See Also== | ==See Also== | ||
Revision as of 00:26, 23 May 2015
General
- Type: Antihistamine, H1 antagonist
- Dosage Forms: 12.5, 25, 32 mg oral tablet; 25 mg oral chewable tablet
- Common Trade Names: Univert, Vertin-32, Dramamine less drowsy, Motion-Time
Adult Dosing
Vertigo
- 25mg PO QID
Motion Sickness
- 25-100 mg PO 1 hour before activity. May repeat q24h
Pediatric Dosing
- >= 12 yrs old: Adult dosing
- < 12 yrs: No dosing specified in drug insert
Special Populations
- Pregnancy Rating: B
- Lactation: Excretion in breast milk unknown
- Renal Dosing: n/a
- Hepatic Dosing: n/a
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- CNS depression
- Caution in asthma, glaucoma, BPH, pyloric obstruction
Common
- Drowsiness, fatigue
Pharmacology
- Onset: 1 hour
- Half-life: 5 hours
- Metabolism: Hepatic
- Excretion: Urine and feces
- Mechanism of Action: Central anticholinergic; blocks chemoreceptor trigger zone. Decreases middle ear excitability, blocks vestibular-cerebellar pathways
See Also
Sources
Lexicomp