Sulfadiazine: Difference between revisions
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==Adult Dosing== | ==Adult Dosing== | ||
===Indications by Disease=== | |||
{{#ask: [[Has DrugName::Sulfadiazine]] [[Has Population::Adult]] | |||
|?Treats disease=Disease | |||
|?Has Dose=Dose | |||
|?Has Context=Context | |||
|format=table | |||
|limit=50 | |||
|mainlabel=- | |||
|headers=show | |||
|sort=Treats disease | |||
}} | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
===Indications by Disease=== | |||
{{#ask: [[Has DrugName::Sulfadiazine]] [[Has Population::Pediatric]] | |||
|?Treats disease=Disease | |||
|?Has Dose=Dose | |||
|?Has Context=Context | |||
|format=table | |||
|limit=50 | |||
|mainlabel=- | |||
|headers=show | |||
|sort=Treats disease | |||
}} | |||
==Special Populations== | ==Special Populations== | ||
Revision as of 01:53, 20 March 2026
Administration
- Type: Antibiotic
- Dosage Forms: Tablet, 500mg
- Routes of Administration: Oral
- Common Trade Names:
Adult Dosing
Indications by Disease
| Disease | Dose | Context |
|---|---|---|
| Toxoplasmosis | 1g PO q6hrs | Immunocompetent with Pyrimethamine |
| Toxoplasmosis | 1500mg PO q6hrs | Immunosuppressed with Pyrimethamine |
Pediatric Dosing
Indications by Disease
| Disease | Dose | Context |
|---|---|---|
| Toxoplasmosis | 50mg/kg PO BID | Congenital/Pediatric |
Special Populations
- Pregnancy Rating: C
- Lactation risk: Infant risk has been demonstrated
- Renal dosing: use with caution
- Hepatic dosing: use with caution
Contraindications
- Allergy to class/drug
- Infants <2mo (except to treat congenital toxoplasmosis)
- Pregnant women at term
- Breastfeeding
Adverse Reactions
Serious
- SJS/TEN
- Agranulocytosis, hemolytic anemia, leukopenia, thrombocytopenia, aplastic anemia
- Crystalluria
- Allergic Myocarditis
Common
- Rash
- Nausea/vomiting, diarrhea, abdominal pain
- Tinnitus
- Headache, Depression, Insomnia
Pharmacology
- Half-life: 7-16.8h
- Metabolism: Hepatic
- Excretion: Mostly renal
Mechanism of Action
- Inhibits bacterial synthesis of folic acid