Template:Appendicitis Antibiotics: Difference between revisions
(Add disease=Appendicitis parameter to AntibioticDose calls - fixes aggregation page display issue) |
(Add pediatric complicated section with proper population tags; fix adult complicated doses; add peds ertapenem) |
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''Coverage should extend to [[E. coli|E. coli]], [[Klebsiella|Klebsiella]], [[Proteus|Proteus]], and [[Bacteroides|Bacteroides]] (an anaerobe)'' | |||
''Coverage should extend to [[ | |||
====Adult Simple Appendicitis==== | ====Adult Simple Appendicitis==== | ||
''Antibiotic prophylaxis should be coordinated with surgical consult'' | ''Antibiotic prophylaxis should be coordinated with surgical consult'' | ||
'''Options:''' | '''Options:''' | ||
*{{AntibioticDose|disease=Appendicitis|drug=Cefoxitin|dose=2g IV q6 hours|context=Adult Simple}} OR | *{{AntibioticDose|disease=Appendicitis|drug=Cefoxitin|dose=2g IV q6 hours|context=Adult Simple}} OR | ||
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====Pediatric Simple Appendicitis==== | ====Pediatric Simple Appendicitis==== | ||
'''Options:''' | '''Options:''' | ||
*{{AntibioticDose|disease=Appendicitis|drug=Cefoxitin|dose=40mg/kg IV q6 hours|context=Pediatric Simple|population=Pediatric}} | *{{AntibioticDose|disease=Appendicitis|drug=Cefoxitin|dose=40mg/kg IV q6 hours|context=Pediatric Simple|population=Pediatric}} | ||
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**{{AntibioticDose|disease=Appendicitis|drug=Metronidazole|dose=7.5mg/kg IV q6hrs|context=Pediatric Simple|population=Pediatric}} OR | **{{AntibioticDose|disease=Appendicitis|drug=Metronidazole|dose=7.5mg/kg IV q6hrs|context=Pediatric Simple|population=Pediatric}} OR | ||
**{{AntibioticDose|disease=Appendicitis|drug=Clindamycin|dose=10mg/kg IV q8hrs|context=Pediatric Simple|population=Pediatric}} | **{{AntibioticDose|disease=Appendicitis|drug=Clindamycin|dose=10mg/kg IV q8hrs|context=Pediatric Simple|population=Pediatric}} | ||
*{{AntibioticDose|disease=Appendicitis|drug=Ertapenem|dose=15mg/kg IV q12h (max 1g); >13 years: 1g IV daily|context=Pediatric Simple|population=Pediatric}} | |||
====Complicated Appendicitis==== | ====Adult Complicated Appendicitis==== | ||
''Defined as perforation, abscess, or phlegmon'' | ''Defined as perforation, abscess, or phlegmon'' | ||
'''Options:''' | '''Options:''' | ||
*{{AntibioticDose|disease=Appendicitis|drug=Metronidazole|dose= | *{{AntibioticDose|disease=Appendicitis|drug=Metronidazole|dose=500mg IV q8hrs|context=Adult Complicated}} + | ||
**{{AntibioticDose|disease=Appendicitis|drug=Cefepime|dose= | **{{AntibioticDose|disease=Appendicitis|drug=Cefepime|dose=2g IV q12hrs|context=Adult Complicated}} OR | ||
**{{AntibioticDose|disease=Appendicitis|drug=Ciprofloxacin|dose= | **{{AntibioticDose|disease=Appendicitis|drug=Ciprofloxacin|dose=400mg IV q12hrs|context=Adult Complicated}} OR | ||
**{{AntibioticDose|disease=Appendicitis|drug=Levofloxacin|dose= | **{{AntibioticDose|disease=Appendicitis|drug=Levofloxacin|dose=750mg IV q24hrs|context=Adult Complicated}} OR | ||
**{{AntibioticDose|disease=Appendicitis|drug=Aztreonam|dose= | **{{AntibioticDose|disease=Appendicitis|drug=Aztreonam|dose=2g IV q8hrs|context=Adult Complicated}} | ||
*{{AntibioticDose|disease=Appendicitis|drug=Imipenem/Cilastatin|dose= | *{{AntibioticDose|disease=Appendicitis|drug=Imipenem/Cilastatin|dose=500mg IV q6hrs|context=Adult Complicated}} | ||
*{{AntibioticDose|disease=Appendicitis|drug=Meropenem|dose= | *{{AntibioticDose|disease=Appendicitis|drug=Meropenem|dose=1g IV q8hrs|context=Adult Complicated}} | ||
*{{AntibioticDose|disease=Appendicitis|drug=Piperacillin/Tazobactam|dose= | *{{AntibioticDose|disease=Appendicitis|drug=Piperacillin/Tazobactam|dose=4.5g IV q8hrs|context=Adult Complicated}} | ||
''Cautious use should be applied to use of [[ | ====Pediatric Complicated Appendicitis==== | ||
'''Options:''' | |||
*{{AntibioticDose|disease=Appendicitis|drug=Metronidazole|dose=7.5mg/kg IV q6hrs|context=Pediatric Complicated|population=Pediatric}} + | |||
**{{AntibioticDose|disease=Appendicitis|drug=Cefepime|dose=50mg/kg IV q12hrs (max 2g)|context=Pediatric Complicated|population=Pediatric}} OR | |||
**{{AntibioticDose|disease=Appendicitis|drug=Aztreonam|dose=30mg/kg IV q8hrs|context=Pediatric Complicated|population=Pediatric}} | |||
*{{AntibioticDose|disease=Appendicitis|drug=Imipenem/Cilastatin|dose=25mg/kg IV q6hrs (max 500mg)|context=Pediatric Complicated|population=Pediatric}} | |||
*{{AntibioticDose|disease=Appendicitis|drug=Meropenem|dose=20mg/kg IV q8hrs (max 1g)|context=Pediatric Complicated|population=Pediatric}} | |||
*{{AntibioticDose|disease=Appendicitis|drug=Piperacillin/Tazobactam|dose=100mg/kg IV q8hrs (max 4.5g)|context=Pediatric Complicated|population=Pediatric}} | |||
''Cautious use should be applied to use of [[fluoroquinolones|fluoroquinolones]] in complicated pediatric appendicitis due to the risk of tendon injury'' | |||
Latest revision as of 12:50, 20 March 2026
Coverage should extend to E. coli, Klebsiella, Proteus, and Bacteroides (an anaerobe)
Adult Simple Appendicitis
Antibiotic prophylaxis should be coordinated with surgical consult
Options:
- Cefoxitin 2g IV q6 hours OR
- Cefotetan 2g IV q12 hours OR
- Moxifloxacin 400mg IV once daily OR
- Ertapenem 1g IV once daily
Pediatric Simple Appendicitis
Options:
- Cefoxitin 40mg/kg IV q6 hours
- Cefotetan 40mg/kg IV q12 hours
- Gentamicin 2.5mg/kg IV q8hrs +
- Metronidazole 7.5mg/kg IV q6hrs OR
- Clindamycin 10mg/kg IV q8hrs
- Ertapenem 15mg/kg IV q12h (max 1g); >13 years: 1g IV daily
Adult Complicated Appendicitis
Defined as perforation, abscess, or phlegmon
Options:
- Metronidazole 500mg IV q8hrs +
- Cefepime 2g IV q12hrs OR
- Ciprofloxacin 400mg IV q12hrs OR
- Levofloxacin 750mg IV q24hrs OR
- Aztreonam 2g IV q8hrs
- Imipenem/Cilastatin 500mg IV q6hrs
- Meropenem 1g IV q8hrs
- Piperacillin/Tazobactam 4.5g IV q8hrs
Pediatric Complicated Appendicitis
Options:
- Metronidazole 7.5mg/kg IV q6hrs +
- Imipenem/Cilastatin 25mg/kg IV q6hrs (max 500mg)
- Meropenem 20mg/kg IV q8hrs (max 1g)
- Piperacillin/Tazobactam 100mg/kg IV q8hrs (max 4.5g)
Cautious use should be applied to use of fluoroquinolones in complicated pediatric appendicitis due to the risk of tendon injury