Levothyroxine: Difference between revisions
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==Administration== | ==Administration== | ||
*Type: Endocrine | *Type: Endocrine, synthetic hormone | ||
*Dosage Forms: | *Dosage Forms: Tablet 13mcg, 25mcg, 50mcg, 75mcg, 88mcg, 100mcg, 112mcg, 125mcg, 137mcg, 150mcg, 175mcg, 200mcg. IV 100mcg, 200mcg, 500mcg | ||
*Routes of Administration: PO, IV | *Routes of Administration: PO, IV | ||
*Common Trade Names: Synthroid | *Common Trade Names: Synthroid | ||
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==Comments== | ==Comments== | ||
==Indications by Condition== | |||
''The following table is automatically generated from disease/condition pages across WikEM.'' | |||
{{#ask:[[Has DrugName::Levothyroxine]] | |||
|?Has Indication=Indication | |||
|?Has Dose=Dose | |||
|?Has Context=Context | |||
|?Has Route=Route | |||
|?Has Population=Population | |||
|format=table | |||
|headers=plain | |||
|mainlabel=- | |||
|sort=Has Indication | |||
|limit=50 | |||
}} | |||
==See Also== | ==See Also== | ||
| Line 53: | Line 70: | ||
<references/> | <references/> | ||
[[Category:Pharmacology]] | [[Category:Pharmacology]] | ||
[[Category:Endocrinology]] | |||
Latest revision as of 21:57, 20 March 2026
Administration
- Type: Endocrine, synthetic hormone
- Dosage Forms: Tablet 13mcg, 25mcg, 50mcg, 75mcg, 88mcg, 100mcg, 112mcg, 125mcg, 137mcg, 150mcg, 175mcg, 200mcg. IV 100mcg, 200mcg, 500mcg
- Routes of Administration: PO, IV
- Common Trade Names: Synthroid
Adult Dosing
- Myxedema coma: 300-500 mcg IV x1, then 50-100mcg IV daily until able to tolerate PO
- Hypothyroidism: doses vary
Pediatric Dosing
- Hypothyroid: Doses vary, 1.7-15 mcg/kg/day PO
Special Populations
- Pregnancy Rating: A
- Lactation risk: Infant risk minimal
- Renal dosing: Not defined
- Hepatic dosing: Not defined
Contraindications
- Allergy to class/drug, hypersensitivity to glycerol
- Uncorrected adrenal insufficiency (may precipitate acute adrenal crisis)
- Acute MI
- Subclinical or overt thyrotoxicosis, nontoxic diffuse goiter, nodular thyroid disease
Adverse Reactions
Serious
- MI, heart failure, tachycardia, cardiac arrest
- Pseudotumor, seizure
- Dyspnea
- Hyperthyroid
- Decreased bone mineral density, hip fracture
Common
- Palpitations
- Diarrhea
- Anxiety, insomnia, fatigue, sweating, weight loss
- Alopecia
Pharmacology
- Half-life: 6-7 days
- Metabolism: Hepatic
- Excretion: Renal, fecal
Mechanism of Action
- Synthetic thyroid hormone (T4)
Comments
Indications by Condition
The following table is automatically generated from disease/condition pages across WikEM.