Methohexital: Difference between revisions

Latest revision as of 21:58, 20 March 2026

General

Type: Sedative agents
Dosage Forms:
Common Trade Names: Brevital

Adult Dosing

Dose 1-1.5mg/kg

Pediatric Dosing

>1mo: 6.6-10 mg/kg IM administered as a 5% (50 mg/mL) solution

Special Populations

Pregnancy Rating: B
Lactation risk: Excreted in breastmilk
Renal Dosing: Caution
Hepatic Dosing: Caution

Contraindications

Allergy to class/drug
Porphyria
Relative: cardiovascular disease, hypotension, respiratory disease
Caution if: severe anemia, extreme obesity, debilitated patients, renal/hepatic/endocrine/circulatory dysfunction, obstructive pulmonary disease, severe HTN, status asthmaticus

Adverse Reactions

Serious

Laryngospasm
Apnea, respiratory depression
Hypotension
Myocardial depression
Seizures

Common

Hiccups, muscle twitching, coughing
Shivering
Salivation
Emergence reaction
Anxiety, restlessness
Headache
Nausea/vomiting, abdominal pain
Erythema, pruritus, urticaria
Rhinitis
Thrombophlebitis
Injection site pain

Pharmacology

Half-life: 3-6h
Metabolism: Hepatic
Excretion: Urine
Mechanism of Action: ultra short acting barbituate
Onset < 1 minute; Duration 10 minutes

Comments

No analgesic effect

Indications by Condition

The following table is automatically generated from disease/condition pages across WikEM.

Indication	Dose	Context	Route	Population
Procedural sedation	0.75-1 mg/kg	Procedural sedation	IV	Adult

References

Authors:

@@ Line 8: / Line 8: @@
 ==Pediatric Dosing==
+*>1mo: 6.6-10 mg/kg IM administered as a 5% (50 mg/mL) solution
 ==Special Populations==
-*[[Drug Ratings in Pregnancy|Pregnancy Rating]]:
+*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: B
-*[[Lactation risk categories|Lactation risk]]:
+*[[Lactation risk categories|Lactation risk]]: Excreted in breastmilk
-*Renal Dosing
+*Renal Dosing: Caution
-**Adult
+*Hepatic Dosing: Caution
-**Pediatric
-*Hepatic Dosing
-**Adult
-**Pediatric
 ==Contraindications==
 *Allergy to class/drug
+*Porphyria
+*Relative: cardiovascular disease, hypotension, respiratory disease
+*Caution if: severe anemia, extreme obesity, debilitated patients, renal/hepatic/endocrine/circulatory dysfunction, obstructive pulmonary disease, severe HTN, status asthmaticus
 ==Adverse Reactions==
 ===Serious===
 *Laryngospasm
+*Apnea, respiratory depression
+*Hypotension
+*Myocardial depression
+*Seizures
 ===Common===
+*Hiccups, muscle twitching, coughing
+*Shivering
+*Salivation
+*Emergence reaction
+*Anxiety, restlessness
+*Headache
+*Nausea/vomiting, abdominal pain
+*Erythema, pruritus, urticaria
+*Rhinitis
+*Thrombophlebitis
+*Injection site pain
 ==Pharmacology==
-*Half-life:
+*Half-life: 3-6h
-*Metabolism:
+*Metabolism: Hepatic
-*Excretion:
+*Excretion: Urine
-*Mechanism of Action:
+*Mechanism of Action: ultra short acting barbituate
 *Onset < 1 minute; Duration 10 minutes
 ==Comments==
 *No analgesic effect
+==Indications by Condition==
+''The following table is automatically generated from disease/condition pages across WikEM.''
+{{#ask:[[Has DrugName::Methohexital]]
+ |?Has Indication=Indication
+ |?Has Dose=Dose
+ |?Has Context=Context
+ |?Has Route=Route
+ |?Has Population=Population
+ |format=table
+ |headers=plain
+ |mainlabel=-
+ |sort=Has Indication
+ |limit=50
+}}
 ==See Also==
-*[[Procedural Sedation]]
+*[[Procedural sedation]]
 ==References==
 <references/>
 [[Category:Pharmacology]]