Mupirocin: Difference between revisions
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==General== | ==General== | ||
*Type: | *Type: [[Antibiotic]], Topical | ||
*Dosage Forms: 2% cream, ointment | *Dosage Forms: 2% cream, ointment | ||
*Routes of Administration: topical | *Routes of Administration: topical | ||
| Line 55: | Line 55: | ||
*Excretion: urine <3% | *Excretion: urine <3% | ||
*Mechanism of Action: bacteriostatic or bactericidal, depending on susceptibility and concentration; reversibly binds to isoleucyl-tRNA synthetase, inhibiting protein synthesis (monoxycarbolic acid) | *Mechanism of Action: bacteriostatic or bactericidal, depending on susceptibility and concentration; reversibly binds to isoleucyl-tRNA synthetase, inhibiting protein synthesis (monoxycarbolic acid) | ||
==Indications by Disease== | |||
''Autogenerated from disease pages.'' | |||
===Adult=== | |||
{{#ask: [[Has DrugName::Mupirocin]] [[Has Population::Adult]] | |||
|?Treats disease=Disease | |||
|?Has Dose=Dose | |||
|?Has Context=Context | |||
|format=table | |||
|limit=50 | |||
|mainlabel=- | |||
|headers=show | |||
|sort=Treats disease | |||
}} | |||
===Pediatric=== | |||
{{#ask: [[Has DrugName::Mupirocin]] [[Has Population::Pediatric]] | |||
|?Treats disease=Disease | |||
|?Has Dose=Dose | |||
|?Has Context=Context | |||
|format=table | |||
|limit=50 | |||
|mainlabel=- | |||
|headers=show | |||
|sort=Treats disease | |||
}} | |||
==See Also== | ==See Also== | ||
| Line 61: | Line 87: | ||
<references/> | <references/> | ||
[[Category:Pharmacology]] | [[Category:Pharmacology]] | ||
[[Category:ID]] | |||
Latest revision as of 19:29, 15 April 2026
General
- Type: Antibiotic, Topical
- Dosage Forms: 2% cream, ointment
- Routes of Administration: topical
- Common Trade Names: Bactroban, Centany
Adult Dosing
Impetigo
- apply ointment TID x 7-14 days
Skin infections, bacterial
- apply cream TID x 10 days
Pediatric Dosing
Impetigo (2mos and older)
- apply ointment TID x 7-14 days
Skin infections, bacterial (3mos and older)
- apply cream TID x 10 days
Special Populations
- Pregnancy Rating: B
- Lactation risk: probably safe
Renal Dosing
- Adult: NA
- Pediatric: NA
Hepatic Dosing
- Adult: NA
- Pediatric: NA
Contraindications
- Allergy to class/drug
- large open wounds
- caution if renal impairment, mod-severe
Adverse Reactions
Serious
- hypersensitivity run
- anaphylaxis
- C. difficile-assoc diarrhea
- superinfection (prolonged use)
Common
- nausea
- burning
- headache
- pruritus
- pain
- stinging
Pharmacology
- Half-life: 20-40 min
- Metabolism: liver; CYP450; <0.3% systemic absorption
- Excretion: urine <3%
- Mechanism of Action: bacteriostatic or bactericidal, depending on susceptibility and concentration; reversibly binds to isoleucyl-tRNA synthetase, inhibiting protein synthesis (monoxycarbolic acid)
Indications by Disease
Autogenerated from disease pages.
Adult
| Disease | Dose | Context |
|---|---|---|
| Balanoposthitis | cream BID | Antibacterial |
| Impetigo | 2% ointment q8hrs x 5 days | For nonbullous impetigo, topical antibiotics are as effective as oral antibiotics |
Pediatric
| Disease | Dose | Context |
|---|---|---|
| Impetigo | 2% ointment applied TID x 5 days | Pediatric Topical |