Theophylline: Difference between revisions
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===Common=== | ===Common=== | ||
*nausea | |||
*vomiting | |||
*headache | |||
*insomnia | |||
*diarrhea | |||
*irritability | |||
*restlessness | |||
*tremor | |||
*diuresis, transient | |||
==Pharmacology== | ==Pharmacology== | ||
Revision as of 22:23, 30 June 2015
General
- Type:
- Dosage Forms:
- Common Trade Names:
Adult Dosing
Pediatric Dosing
Special Populations
- Pregnancy Rating: C
- Lactation: Probably Safe
- Renal Dosing
- Adult: no adjustment
- Pediatric: <3 mo: decr. dose amount not defined; >3 mo: no adjustment
- Hepatic Dosing
- Adult: decr. dose amount not defined
- Pediatric: decr. dose amount not defined
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- seizures
- arrhythmias
- hypotension
- shock
- exfoliative dermatitis
Common
- nausea
- vomiting
- headache
- insomnia
- diarrhea
- irritability
- restlessness
- tremor
- diuresis, transient
Pharmacology
- Half-life: 8h
- Metabolism: liver; CYP450: 1A2, 2E1, 3A3
- Excretion: urine (10% unchanged)
- Mechanism of Action: exact mechanism unknown; increases cAMP; antagonizes adenosine receptors (methylxanthine)