Theophylline: Difference between revisions
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==Contraindications== | ==Contraindications== | ||
*Allergy to class/drug | *Allergy to class/drug | ||
*caution if PUD, active | |||
*caution if seizure disorder | |||
*caution if arrhythmias | |||
*caution if CHF | |||
*caution if pulmonary edema, acute | |||
*caution if cor pulmonale | |||
*caution if hepatic impairment | |||
*caution if hypothyroidism | |||
*caution if febrile | |||
*caution if sepsis w/ multi-organ failure | |||
*caution if shock | |||
*caution if smoking habit changes | |||
*caution if neonates or infants | |||
*caution in elderly pts | |||
==Adverse Reactions== | ==Adverse Reactions== | ||
Revision as of 22:24, 30 June 2015
General
- Type:
- Dosage Forms:
- Common Trade Names:
Adult Dosing
Pediatric Dosing
Special Populations
- Pregnancy Rating: C
- Lactation: Probably Safe
- Renal Dosing
- Adult: no adjustment
- Pediatric: <3 mo: decr. dose amount not defined; >3 mo: no adjustment
- Hepatic Dosing
- Adult: decr. dose amount not defined
- Pediatric: decr. dose amount not defined
Contraindications
- Allergy to class/drug
- caution if PUD, active
- caution if seizure disorder
- caution if arrhythmias
- caution if CHF
- caution if pulmonary edema, acute
- caution if cor pulmonale
- caution if hepatic impairment
- caution if hypothyroidism
- caution if febrile
- caution if sepsis w/ multi-organ failure
- caution if shock
- caution if smoking habit changes
- caution if neonates or infants
- caution in elderly pts
Adverse Reactions
Serious
- seizures
- arrhythmias
- hypotension
- shock
- exfoliative dermatitis
Common
- nausea
- vomiting
- headache
- insomnia
- diarrhea
- irritability
- restlessness
- tremor
- diuresis, transient
Pharmacology
- Half-life: 8h
- Metabolism: liver; CYP450: 1A2, 2E1, 3A3
- Excretion: urine (10% unchanged)
- Mechanism of Action: exact mechanism unknown; increases cAMP; antagonizes adenosine receptors (methylxanthine)