Multiple sclerosis

Background

• CNS myelin destruction causes variable motor, sensory, visual and cerebellar dysfunction

Types

• Relapsing/remitting (most common)
  • Relapse (days-months) followed by remission
• Secondary progressive
  • Relapses and partial recoveries occur, but disability doesn't fade away between cycles
• Primary progressive
  • Symptoms progress slowly and steadily without remission
• Progressive relapsing
  • Similar to primary progressive but with superimposed flares

Clinical Features

• Classic pt has multiple presentations for neuro symptoms of different areas of pathology
  • Pt often has resolution of the earlier symptoms
• Symptoms worsen w/ increases in body temperature (Uhthoff's phenomenon)
• Muscle/sensory signs:
  • Lower extremity weakness usually worse than upper extremity
  • Upper motor neuron signs:
    • Hyperreflexia
    • Positive Babinski
  • Decrease in proprioception / pain/temp sensation
  • Lhermitte sign
    • Electric shock sensation radiating down back into arms/egs from neck flexion
• Optic neuritis
  • Initial sign in 30% of pts
  • Vision loss (usually unilateral) often preceded by retrobulbar pain
  • Blurred vision
  • Nystagus
  • Diplopia
  • Internuclear ophthalmoplegia
    • Abnormal eye adduction bilaterally and horizontal nystagmus
• Dysautonomia
  • Urinary retention (increased risk of UTI/pyelo)
  • Constipation or incontinence
  • Sexual dysfunction (males)

Differential Diagnosis

Weakness

• Neuromuscular weakness
  • Upper motor neuron:
    • CVA
    • Hemorrhagic stroke
    • Multiple sclerosis
    • Amyotrophic Lateral Sclerosis (ALS) (upper and lower motor neuron)
  • Lower motor neuron:
    • Spinal and bulbar muscular atrophy (Kennedy's syndrome)
  • Spinal cord disease:
    • Infection (Epidural abscess)
    • Infarction/ischemia
    • Trauma (Spinal Cord Syndromes)
    • Inflammation (Transverse Myelitis)
      • Acute flaccid myelitis
    • Degenerative (Spinal muscular atrophy)
    • Tumor
  • Peripheral nerve disease:
    • Guillain-Barre syndrome
    • Toxins (Ciguatera)
    • Tick paralysis
    • Diabetic peripheral neuropathy
  • Neuromuscular junction disease:
    • Myasthenia gravis crisis
    • Botulism
    • Organophosphate toxicity
    • Lambert-Eaton myasthenic syndrome
  • Muscle disease:
    • Rhabdomyolysis
    • Dermatomyositis
    • Polymyositis
    • Alcoholic myopathy
• Non-neuromuscular weakness
  • Can't miss diagnoses:
    • ACS
    • Arrhythmia/Syncope
    • Severe infection/Sepsis
    • Hypoglycemia
    • Periodic paralysis (electrolyte disturbance, K, Mg, Ca)
      • Hypokalemic periodic paralysis
      • Thyrotoxic periodic paralysis
    • Respiratory failure
  • Emergent Diagnoses:
    • Symptomatic Anemia
    • Severe dehydration
    • Hypothyroidism
    • Polypharmacy
    • Malignancy
    • Aortic disease - occlusion, stenosis, dissection
  • Other causes of weakness and paralysis
    • Acute intermittent porphyria (ascending weakness)

Diagnosis

Work-Up

• LP
  • IgG
  • Albumin
  • Oligoclonal bands
  • myelin basic protein
  • Cell count
  • Glucose
  • Protein
  • Gm stain
• CBC, Chemistry
• UA
• MRI w/ GAD of brain (+/- spine)

Evaluation

• MRI
  • Multiple lesions in supratentorial white matter, paraventricular area, spinal cord
• CSF
  • Elevated protein and gamma-globulin (increased oligoclonal bands)

Treatment

• Fever must be reduced to minimize weakness assoc w/ elevated temperature
• Abx for UTI/pyelo
• High-dose steroid therapy for relapses

Disposition

• Hospitalization indicated for:
  • Any disease exacerbation a/w significant morbidity
  • IV abx or steroid therapy required
  • Depression and significant risk of suicide

See Also

• Optic Neuritis