Prochlorperazine

General

• Type: anti-psychotic and anti-emetic
• Dosage Forms: 5, 10
• Routes of Administration: IV, PO
• Common Trade Names: Compazine

Adult Dosing

Headache

• 10 mg IV (slow push or in 1L IV NS)

Nausea/Vomiting

• 5-10 mg PO or IV q6-8 hours
• Max: 40mg/day

Pediatric Dosing

nausea/vomiting, severe

2 yo and older, 9-14 kg

• 2.5 mg PO q12-24 h; Max 7.5 mg/day

2 yo and older, 14-18 kg

• 2.5 mg PO q8-12 h; Max 10 mg/day

2 yo and older, 18-39 kg

• 2.5 mg PO q8 hr; Max 15 mg/day

2 yo and older, >39 kg

• 5 mg PO q6-8 h, Max: 20 mg/day

Schizophrenia

2-5 yo

• 2.5 - 5 mg PO q6-8 hr, Max 20 mg/day

6-12 yo

• 2.5-5 mg PO q6-8 hr, Max 25 mg/day

Special Populations

• Pregnancy Rating: Pregnancy category C
• Lactation risk: Safety unknown
• Renal Dosing: not defined
• Hepatic Dosing: not defined

Contraindications

• Allergy to class/drug

Adverse Reactions

Serious

• tardive dyskinesia
• neuroleptic malignant syndrome
• blood dyscrasias
• agranulocytosis
• thrombocytopenic purpura
• orthostatic hypotension
• extrapyramidal symptoms
• cholestatic jaundice
• hepatotoxicity
• QT prolongation
• cardiac arrest
• seizures
• anaphylactoid reactions
• lupus erythematosus
• priapism
• heat stroke
• neonatal extrapyramidal symptoms (3rd trimester use)
• neonatal withdrawal symptoms (3rd trimester use)

Common

• drowsiness
• dizziness
• blurred vision
• xerostomia
• constipation
• urinary retention
• headache
• nasal congestion
• nausea
• menstrual irregularities
• amenorrhea
• weight gain
• hyperprolactinemia
• hyperglycemia
• hypoglycemia
• insomnia
• agitation
• sexual dysfunction
• photosensitivity
• impaired body temperature regulation

Pharmacology

• Half-life:
• Metabolism:
• Excretion:
• Mechanism of Action: