Naloxone

General

• Type: Opioid antagonists
• Dosage Forms:
• Common Trade Names: Narcan

Adult Dosing

Opioid toxicity

• Bolus (May repeat q3min up to max dose 10mg
  • Apneic or near-apneic - 2mg IV
  • Opioid-naive with minimal respiratory depression - 0.4mg IV
  • Opioid-dependent with minimal respiratory depression - 0.05mg IV
• Infusion
  • Only give if the pt responded to the bolus and required repeat administration
  • Step 1: Determine the "wake-up dose" or bolus required to wake the pt
  • Step 2: Give 2/3 of the "wake-up dose" per hr; mix in 1L D5W

Special Populations

• Pregnancy Rating:
• Lactation:
• Renal Dosing
  • Adult
  • Pediatric
• Hepatic Dosing
  • Adult
  • Pediatric

Contraindications

• Allergy to class/drug

Adverse Reactions

• Opioid withdrawal
• Serious complications are rare

Pharmacology

• Half-life:
• Metabolism:
• Excretion:
• Mechanism of Action:
• Onset of action - 1-2min
• Duration of action - 20-90min (may be less than that of the ingested opioid)