D-dimer: Difference between revisions
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==Differential Diagnosis== | |||
*'''Factors that can cause false-negative D-dimer''' | *'''Factors that can cause false-negative D-dimer''' | ||
**Symptoms of PE > 3 days | **Symptoms of PE > 3 days | ||
| Line 18: | Line 20: | ||
**Vasculitis | **Vasculitis | ||
**Superficial phlebitis | **Superficial phlebitis | ||
==Diagnosis== | |||
*Traditional cutoff value = 500 | |||
*Age-adjusted (for over 50 years old) = age x 10 | |||
**Maintains high sensitivity while increasing specificity<ref>Sharp AL, et al. An Age-Adjusted D-dimer Threshold for Emergency Department Patients with Suspected Pulmonary Embolus: Accuracy and Clinical Implications. Feb 2016. Annals of EM. 67(2);249-257.</ref> | |||
==See Also== | ==See Also== | ||
*[[Pulmonary Embolism (PE)]] | *[[Pulmonary Embolism (PE)]] | ||
Revision as of 19:35, 26 April 2016
Differential Diagnosis
- Factors that can cause false-negative D-dimer
- Symptoms of PE > 3 days
- Small PE
- Use of qualitative latex fixation test
- Use of anticoagulants
- Factors that can cause false-positive D-dimer
- Cancer and malignancy
- Recent surgery
- Infection (eg, PNA, sepsis)
- Pregnancy
- Age > 70 years
- DIC
- Trauma
- Arterial thrombosis
- ACS/AMI
- Vaso-occlusive sickle cell crisis
- Acute CVA
- Vasculitis
- Superficial phlebitis
Diagnosis
- Traditional cutoff value = 500
- Age-adjusted (for over 50 years old) = age x 10
- Maintains high sensitivity while increasing specificity[1]
See Also
References
- ↑ Sharp AL, et al. An Age-Adjusted D-dimer Threshold for Emergency Department Patients with Suspected Pulmonary Embolus: Accuracy and Clinical Implications. Feb 2016. Annals of EM. 67(2);249-257.