D-dimer: Difference between revisions
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==Differential Diagnosis== | ==Differential Diagnosis== | ||
*'''Factors that can cause false-negative D-dimer''' | *'''Factors that can cause false-negative D-dimer''' | ||
**Symptoms of PE > 3 days | **Symptoms of [[PE]] > 3 days | ||
**Small PE | **Small [[PE]] | ||
**Use of qualitative latex fixation test | **Use of qualitative latex fixation test | ||
**Use of anticoagulants | **Use of anticoagulants | ||
| Line 9: | Line 9: | ||
**Cancer and malignancy | **Cancer and malignancy | ||
**Recent surgery | **Recent surgery | ||
**Infection (eg, PNA, sepsis) | **Infection (eg, [[PNA]], [[sepsis]]) | ||
**Pregnancy | **[[Pregnancy]] | ||
**Age > 70 years | **Age > 70 years | ||
**DIC | **[[DIC]] | ||
**Trauma | **Trauma | ||
**Arterial thrombosis | **Arterial thrombosis | ||
**ACS/AMI | **[[ACS]]/AMI | ||
**Vaso-occlusive sickle cell crisis | **Vaso-occlusive [[sickle cell crisis]] | ||
**Acute CVA | **[[Acute CVA]] | ||
**Vasculitis | **Vasculitis | ||
**Superficial phlebitis | **[[Superficial phlebitis]] | ||
==Diagnosis== | ==Diagnosis== | ||
Revision as of 19:39, 26 April 2016
Differential Diagnosis
- Factors that can cause false-negative D-dimer
- Factors that can cause false-positive D-dimer
- Cancer and malignancy
- Recent surgery
- Infection (eg, PNA, sepsis)
- Pregnancy
- Age > 70 years
- DIC
- Trauma
- Arterial thrombosis
- ACS/AMI
- Vaso-occlusive sickle cell crisis
- Acute CVA
- Vasculitis
- Superficial phlebitis
Diagnosis
- Traditional cutoff value = 500
- Age-adjusted (for over 50 years old) = age x 10
- Maintains high sensitivity while increasing specificity[1]
See Also
External Links
References
- ↑ Sharp AL, et al. An Age-Adjusted D-dimer Threshold for Emergency Department Patients with Suspected Pulmonary Embolus: Accuracy and Clinical Implications. Feb 2016. Annals of EM. 67(2);249-257.