Template:HSV-1 antiviral treatment: Difference between revisions

 
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===Anti-viral Treatment===
===Anti-viral Treatment===
''Treatment does not affect dormant virus in nerve ganglions → recurrent disease remains possible''
====Normal Host====
*Antiviral drug options:
*Options:
**[[Acyclovir]] 40-80mg/kg PO divided in 3-4 doses for 5-7 days
**[[Acyclovir]]  
***Can also be used as a cream or oral suspension (swish and swallow)<ref name="Mohan">Mohan RPS, Verma S, Singh U, Agarwal N. Acute primary herpetic gingivostomatitis. BMJ Case Reports. 2013;2013:bcr2013200074. doi:10.1136/bcr-2013-200074.</ref>
***400 mg PO 5x/day (q4hrs while awake) x 5 days, OR
**[[Valacyclovir]] (significantly higher bioavailability than acyclovir)
***40-80mg/kg PO divided in 3-4 doses for 5-7 days, OR
**[[Famciclovir]]
****Can also be used as a cream or oral suspension (swish and swallow)<ref name="Mohan">Mohan RPS, Verma S, Singh U, Agarwal N. Acute primary herpetic gingivostomatitis. BMJ Case Reports. 2013;2013:bcr2013200074. doi:10.1136/bcr-2013-200074.</ref>
**[[Famciclovir]] 500mg PO BID x 7 days, OR
**[[Valacyclovir]] 2gm PO q12 x 1 day
 
====Immunocompromised====
*Options:
**[[Acyclovir]]
***5 mg/kg IV (over 1 hours) q8h x 7 days, OR
***400mg PO 5x/day x 14-21 days
**[[Famciclovir]] 500mg PO BID x 7 days, OR
**[[Valacyclovir]] 500mg PO BID x 5-10 days

Latest revision as of 20:59, 26 April 2016

Anti-viral Treatment

Normal Host

  • Options:
    • Acyclovir
      • 400 mg PO 5x/day (q4hrs while awake) x 5 days, OR
      • 40-80mg/kg PO divided in 3-4 doses for 5-7 days, OR
        • Can also be used as a cream or oral suspension (swish and swallow)[1]
    • Famciclovir 500mg PO BID x 7 days, OR
    • Valacyclovir 2gm PO q12 x 1 day

Immunocompromised

  • Options:
  1. Mohan RPS, Verma S, Singh U, Agarwal N. Acute primary herpetic gingivostomatitis. BMJ Case Reports. 2013;2013:bcr2013200074. doi:10.1136/bcr-2013-200074.