Template:Peritonitis Antibiotics

Intra-Abdominal Sepsis/Peritonitis

	Harbor-UCLA	Santa Monica-UCLA	Other
Primary	Metronidazole 500mg IV q8hrs Plus one of the following: Ceftriaxone 1g IV once daily Ciprofloxacin 400mg IV q12hrs Cefazolin 1g (30mg/kg) IV q8hrs Levofloxacin 750mg IV once daily	Metronidazole 500mg IV q8h + Vancomycin 15mg/kg/dose IV q12h (Max dose = 1500mg) Plus one of the following: Piperacillin/tazobactam 4.5g IV q6h Ertapenem 1g IV q24h Ceftriaxone 1g IV q24h	One of the following: Piperacillin-tazobactam Ticarcillin-clavulanate 3.1 g IV every 6 hours Ertapenem 1 g every 24 hours Moxifloxacin 400 mg IV every 24 hours
Allergy or prior exposure	Piperacillin/Tazobactam 4.5g (80mg/kg) IV q8hrs OR Metronidazole 500mg IV q8hrs Cefepime 2g IV once daily OR Ciprofloxacin 400mg IV q12hrs OR Levofloxacin 750mg IV once daily Meropenem 1g (20mg/kg) IV q8hrs OR Doripenem 500mg IV q8hrs OR + Aztreonam 2g (30mg/kg) IV q8hrs + Metronidazole 500mg IV q8hrs	aztreonam 2g IV q8h + metronidazole 500mg IV q8h +/- vancomycin 15mg/kg/dose IV q12h (Max dose = 1500mg)

Harbor

Moderate

• Metronidazole 500mg IV q8hrs PLUS
  • Ceftriaxone 1g IV once daily OR
  • Ciprofloxacin 400mg IV q12hrs OR
  • Cefazolin 1g (30mg/kg) IV q8hrs OR
  • Levofloxacin 750mg IV once daily

Severe

• Piperacillin/Tazobactam 4.5g (80mg/kg) IV q8hrs OR
• Metronidazole 500mg IV q8hrs PLUS
  • Cefepime 2g IV once daily OR
  • Ciprofloxacin 400mg IV q12hrs OR
  • Levofloxacin 750mg IV once daily
• Meropenem 1g (20mg/kg) IV q8hrs OR
• Doripenem 500mg IV q8hrs OR
• Aztreonam 2g (30mg/kg) IV q8hrs + Metronidazole 500mg IV q8hrs

Other

• Piperacillin-tazobactam or ticarcillin-clavulanate, 3.1 g IV every 6 hours; or ertapenem, 1 g every 24 hours; or moxifloxacin, 400 mg IV every 24 hours

Santa Monica

• Primary therapy
  • piperacillin/tazobactam 4.5g IV q6h OR ertapenem 1g IV q24h OR ceftriaxone 1g IV q24h
  • AND, metronidazole 500mg IV q8h
  • vancomycin 15mg/kg/dose IV q12h [Maximum dose of 1500mg]
• If allergy or prior exposure
  • aztreonam 2g IV q8h
  • AND, metronidazole 500mg IV q8h
  • +/- vancomycin 15mg/kg/dose IV q12h [Maximum dose of 1500mg]