Serum sickness: Difference between revisions
(Created page with "==Background== *A type III hypersensitivity reaction **Secondary to injection of anitoxins (e.g. tetanus, rabies) *Reactions secondary to the administration of nonprotein drugs *...") |
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*Reactions secondary to the administration of nonprotein drugs | *Reactions secondary to the administration of nonprotein drugs | ||
**Amoxicillin, cefaclor, cephalexin (Keflex), trimethoprim-sulfamethoxazole | **Amoxicillin, cefaclor, cephalexin (Keflex), trimethoprim-sulfamethoxazole | ||
==Diagnosis== | |||
#Primary occurs 6-21 days after exposure | |||
##1-4 days after subsequent exposures to the same antigen | |||
#Fever | |||
#Arthralgia | |||
#Lymphadenopathy | |||
#Skin eruption (rash) | |||
##Urticaria | |||
##Scarlatiniform rash | |||
##Maculopapular or purpuric lesions | |||
##Erythema multiforme | |||
==DDX== | |||
# Erythema Multiforme | |||
# Mononucleosis | |||
# Polymyositis | |||
# Systemic Lupus Erythematosus | |||
# Tick-Borne Diseases, Rocky Mountain Spotted Fever | |||
# Toxic Epidermal Necrolysis | |||
==Treatment== | ==Treatment== | ||
#D/C antigen | #D/C antigen | ||
#Diphenhydramamine | |||
#Prednisone | |||
==Disposition== | |||
Admit for: | |||
#Significant comorbidities (advanced or very young age, immunocompromised) | |||
#Severe symptoms | |||
#Hemodynamic instability/hypotension | |||
#Unclear diagnosis | |||
==Prognosis== | ==Prognosis== | ||
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#Long-lasting sequelae generally do not occur | #Long-lasting sequelae generally do not occur | ||
#Fatalities are rare and usually are due to continued administration of the antigen | #Fatalities are rare and usually are due to continued administration of the antigen | ||
[[Category:Derm]] | |||
Revision as of 09:29, 19 December 2011
Background
- A type III hypersensitivity reaction
- Secondary to injection of anitoxins (e.g. tetanus, rabies)
- Reactions secondary to the administration of nonprotein drugs
- Amoxicillin, cefaclor, cephalexin (Keflex), trimethoprim-sulfamethoxazole
Diagnosis
- Primary occurs 6-21 days after exposure
- 1-4 days after subsequent exposures to the same antigen
- Fever
- Arthralgia
- Lymphadenopathy
- Skin eruption (rash)
- Urticaria
- Scarlatiniform rash
- Maculopapular or purpuric lesions
- Erythema multiforme
DDX
- Erythema Multiforme
- Mononucleosis
- Polymyositis
- Systemic Lupus Erythematosus
- Tick-Borne Diseases, Rocky Mountain Spotted Fever
- Toxic Epidermal Necrolysis
Treatment
- D/C antigen
- Diphenhydramamine
- Prednisone
Disposition
Admit for:
- Significant comorbidities (advanced or very young age, immunocompromised)
- Severe symptoms
- Hemodynamic instability/hypotension
- Unclear diagnosis
Prognosis
- Symptoms usually last 1-2 weeks before spontaneously subsiding
- Long-lasting sequelae generally do not occur
- Fatalities are rare and usually are due to continued administration of the antigen