Antidotes: Difference between revisions
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{| | {| {{table}} | ||
|- | |- | ||
| | | '''TOXIN''' | ||
TOXIN | | '''ANTIDOTE''' | ||
| ANTIDOTE | |||
|- | |- | ||
| [[Acetaminophen (Tylenol)|Acetaminophen]] | | [[Acetaminophen (Tylenol)|Acetaminophen]] | ||
| | | | ||
[[N-Acetylcysteine]] | *[[N-Acetylcysteine]] | ||
**150mg/kg IV load over 60min; followed by 50mg/kg IV over 4hr and then 100mg/kg IV over 16hr | |||
150mg/kg IV load over 60min; followed by 50mg/kg IV over 4hr and then 100mg/kg IV over 16hr | |||
|- | |- | ||
| [[Anticholinergic toxicity|Anticholinergics]] | | [[Anticholinergic toxicity|Anticholinergics]] | ||
| | | Physostigmine | ||
Physostigmine | |||
|- | |- | ||
| [[Arsenic]] | | [[Arsenic]] | ||
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| [[Benzodiazepines]] | | [[Benzodiazepines]] | ||
| | | | ||
Flumazenil | *Flumazenil | ||
**Adult: 0.2mg IV | |||
Adult: 0.2mg IV | **Peds: 0.01mg/kg IV | ||
Peds: 0.01mg/kg IV | |||
|- | |- | ||
| [[Beta-Blocker Toxicity|Beta blockers]] | | [[Beta-Blocker Toxicity|Beta blockers]] | ||
Revision as of 05:44, 9 June 2016
| TOXIN | ANTIDOTE |
| Acetaminophen |
|
| Anticholinergics | Physostigmine |
| Arsenic | Dimercaprol (BAL) |
| Benzodiazepines |
|
| Beta blockers |
Adult: 3-10mg IV Peds: 50-150mcg/kg IV |
|
Calcium chloride 10% Adult: 10 mL IV Peds: 0.2-0.25 mL/kg IV High Dose Insulin (1 unit/kg/hr) | |
|
Adult: 0.4-2mg IV Peds: 0.1mg/kg IV (max 2mg) | |
| Cyanide |
Hydroxycobalamin OR Cyanide Antidote Kit (Amyl Nitrite, Sodium Nitrite, and Sodium Thiosulfate) |
| Digoxin | Dig Immune Fab |
| Ethylene glycol |
Fomepizole 15mg/kg IV; then 10mg/kg q12h |
| Fluoride | Calcium Gluconate |
| Heparin |
Protamine Sulfate Adult: 25-50mg IV (empiric dose) over 10 minutes Peds: 0.6mg/kg IV (empiric dose) Note: Rapid protamine infusion causes hypotension[1] |
| Iron | Deferoxamine |
| Isoniazid (INH) |
Pyridoxine (Vit B6) Adult: 5gm IV Peds: 1gm/kg regardless of age [2] |
| Lead | EDTA, succimer |
| Mercury | Dimercaprol (BAL) |
| Methanol | Fomepizole
15mi/kg IV; then 10mg/kg q12h |
| Methemoglobinemia | Methylene blue |
| Opiods | Naloxone |
| Organophosphates | Atropine + Pralidoxime |
| Sulfonylurea |
Octreotide Adult: 50–100mcg SC q6hr Peds: 1mcg/kg SC q6hr |
| Tricyclic (TCA) Toxicity |
Bicarbonate 1-2mEq/kg IV bolus followed by 2mEq/kg/hr IV infusion |
| Valproate | L-Carnitine |
| Warfarin | Vitamin K, FFP, Prothrombin Complex Concentrates |
Source
<references>