Antidotes: Difference between revisions
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[[Calcium chloride]] 10% | [[Calcium chloride]] 10% | ||
*Adult: 10 mL IV | |||
*Peds: 0.2-0.25 mL/kg IV | |||
High Dose Insulin (1 unit/kg/hr) | High Dose Insulin (1 unit/kg/hr) | ||
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[[Naloxone]] | [[Naloxone]] | ||
*Adult: 0.4-2mg IV | |||
*Peds: 0.1mg/kg IV (max 2mg) | |||
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| [[Cyanide]] | | [[Cyanide]] | ||
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Protamine Sulfate | Protamine Sulfate | ||
*Adult: 25-50mg IV (empiric dose) over 10 minutes | |||
Adult: 25-50mg IV (empiric dose) over 10 minutes | *Peds: 0.6mg/kg IV (empiric dose) | ||
Peds: 0.6mg/kg IV (empiric dose) | |||
''Note: Rapid protamine infusion causes hypotension''<ref>Hirsh J. et al. "Parenteral anticoagulants: ACCP Evidence-Based Clinical Practice Guidelines. Chest 2008; 133</ref> | ''Note: Rapid protamine infusion causes hypotension''<ref>Hirsh J. et al. "Parenteral anticoagulants: ACCP Evidence-Based Clinical Practice Guidelines. Chest 2008; 133</ref> | ||
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[[Pyridoxine]] (Vit B6) | [[Pyridoxine]] (Vit B6) | ||
*Adult: 5gm IV | |||
Adult: 5gm IV | *Peds: 1gm/kg regardless of age <ref>Minns, A. et al. Isoniazid-Induced Status Epilepticus in a Pediatric Patient After Inadequate Pyridoxine Therapy. Pediatric Emergency Care. 2010:26(5)380-381</ref> | ||
Peds: 1gm/kg regardless of age <ref>Minns, A. et al. Isoniazid-Induced Status Epilepticus in a Pediatric Patient After Inadequate Pyridoxine Therapy. Pediatric Emergency Care. 2010:26(5)380-381</ref> | |||
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| [[Methanol Toxicity|Methanol]] | | [[Methanol Toxicity|Methanol]] | ||
| Fomepizole | | | ||
15mi/kg IV; then 10mg/kg q12h<br> | [[Fomepizole]] | ||
*15mi/kg IV; then 10mg/kg q12h<br> | |||
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| [[Methemoglobinemia]] | | [[Methemoglobinemia]] | ||
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Octreotide | Octreotide | ||
*Adult: 50–100mcg SC q6hr | |||
Adult: 50–100mcg SC q6hr | *Peds: 1mcg/kg SC q6hr | ||
Peds: 1mcg/kg SC q6hr | |||
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| [[Tricyclic (TCA) Toxicity]] | | [[Tricyclic (TCA) Toxicity]] | ||
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Bicarbonate | [[Bicarbonate]] | ||
*1-2mEq/kg IV bolus followed by 2mEq/kg/hr IV infusion | |||
1-2mEq/kg IV bolus followed by 2mEq/kg/hr IV infusion | |||
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| [[Valproic acid toxicity|Valproate]] | | [[Valproic acid toxicity|Valproate]] | ||
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== | == References == | ||
<references> | <references> | ||
[[Category:Toxicology]] | [[Category:Toxicology]] | ||
Revision as of 05:56, 9 June 2016
| TOXIN | ANTIDOTE |
| Acetaminophen |
|
| Anticholinergics | Physostigmine |
| Arsenic | Dimercaprol (BAL) |
| Benzodiazepines |
|
| Beta blockers |
|
| Ca channel blockers |
Calcium chloride 10%
High Dose Insulin (1 unit/kg/hr) |
| Clonidine |
|
| Cyanide |
Hydroxycobalamin OR Cyanide Antidote Kit (Amyl Nitrite, Sodium Nitrite, and Sodium Thiosulfate) |
| Digoxin | Dig Immune Fab |
| Ethylene glycol |
Fomepizole
|
| Fluoride | Calcium Gluconate |
| Heparin |
Protamine Sulfate
Note: Rapid protamine infusion causes hypotension[1] |
| Iron | Deferoxamine |
| Isoniazid (INH) |
Pyridoxine (Vit B6)
|
| Lead | EDTA, succimer |
| Mercury | Dimercaprol (BAL) |
| Methanol |
|
| Methemoglobinemia | Methylene blue |
| Opiods | Naloxone |
| Organophosphates | Atropine + Pralidoxime |
| Sulfonylurea |
Octreotide
|
| Tricyclic (TCA) Toxicity |
|
| Valproate | L-Carnitine |
| Warfarin | Vitamin K, FFP, Prothrombin Complex Concentrates |
References
<references>