Naloxone: Difference between revisions
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**Opioid-dependent with minimal respiratory depression - 0.05mg IV | **Opioid-dependent with minimal respiratory depression - 0.05mg IV | ||
*Infusion | *Infusion | ||
**Only give if the | **Only give if the patient responded to the bolus and required repeat administration | ||
**Step 1: Determine the "wake-up dose" or bolus required to wake the pt | **Step 1: Determine the "wake-up dose" or bolus required to wake the pt | ||
**Step 2: Give 2/3 of the "wake-up dose" per hr; mix in 1L D5W | **Step 2: Give 2/3 of the "wake-up dose" per hr; mix in 1L D5W | ||
Revision as of 21:20, 1 July 2016
General
- Type: Opioid antagonists
- Dosage Forms:
- Common Trade Names: Narcan
Adult Dosing
Opioid toxicity
- Bolus (May repeat q3min up to max dose 10mg
- Apneic or near-apneic - 2mg IV
- Opioid-naive with minimal respiratory depression - 0.4mg IV
- Opioid-dependent with minimal respiratory depression - 0.05mg IV
- Infusion
- Only give if the patient responded to the bolus and required repeat administration
- Step 1: Determine the "wake-up dose" or bolus required to wake the pt
- Step 2: Give 2/3 of the "wake-up dose" per hr; mix in 1L D5W
Pediatric Dosing
Special Populations
- Pregnancy Rating:
- Lactation:
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
Adverse Reactions
- Opioid withdrawal
- Serious complications are rare
Pharmacology
- Half-life:
- Metabolism:
- Excretion:
- Mechanism of Action:
- Onset of action - 1-2min
- Duration of action - 20-90min (may be less than that of the ingested opioid)