Cyclospora: Difference between revisions
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==Signs/Symptoms== | ==Signs/Symptoms== | ||
*watery (sometimes explosive) diarrhea, loss of appetite, weight loss, | *watery (sometimes explosive) [[diarrhea]], loss of appetite, weight loss, [[abdominal pain/cramps, bloating, increased flatus, [[nausea]], and fatigue | ||
*can last days to over a month | *can last days to over a month | ||
*In immunocompromised hosts, cyclospora may cause severe, intractable, voluminous diarrhea resembling cryptosporidiosis. Extraintestinal disease in patients with AIDS may include cholecystitis and disseminated infection. | *In immunocompromised hosts, cyclospora may cause severe, intractable, voluminous diarrhea resembling cryptosporidiosis. Extraintestinal disease in patients with [[AIDS]] may include cholecystitis and disseminated infection. | ||
== | ==Evaluation== | ||
*stool O&P | *stool O&P | ||
*Detection is facilitated by staining stool samples with modified acid-fast stain or modified safranin stain. Multiple (≥ 3) stool specimens may be needed because cyst secretion may be intermittent (2) | *Detection is facilitated by staining stool samples with modified acid-fast stain or modified safranin stain. Multiple (≥ 3) stool specimens may be needed because cyst secretion may be intermittent (2) | ||
==Management== | ==Management== | ||
*Bactrim: | *[[Bactrim]]: 160mg TMP and 800mg SMX PO BID for 7 to 10 days for cyclosporiasis or for 10 days. Children are given 5mg/kg TMP and 25mg/kg SMX PO BID for the same number of days. | ||
*Immunocompromised patients may require higher doses and longer duration of treatment, and treatment of acute infection is usually followed by long-term suppressive therapy | *Immunocompromised patients may require higher doses and longer duration of treatment, and treatment of acute infection is usually followed by long-term suppressive therapy | ||
Latest revision as of 01:24, 22 July 2016
Background
- one celled microscopic parasite that causes intestinal infection
- fecal-oral transmission
- endemic in tropical and subtropical regions
Signs/Symptoms
- watery (sometimes explosive) diarrhea, loss of appetite, weight loss, [[abdominal pain/cramps, bloating, increased flatus, nausea, and fatigue
- can last days to over a month
- In immunocompromised hosts, cyclospora may cause severe, intractable, voluminous diarrhea resembling cryptosporidiosis. Extraintestinal disease in patients with AIDS may include cholecystitis and disseminated infection.
Evaluation
- stool O&P
- Detection is facilitated by staining stool samples with modified acid-fast stain or modified safranin stain. Multiple (≥ 3) stool specimens may be needed because cyst secretion may be intermittent (2)
Management
- Bactrim: 160mg TMP and 800mg SMX PO BID for 7 to 10 days for cyclosporiasis or for 10 days. Children are given 5mg/kg TMP and 25mg/kg SMX PO BID for the same number of days.
- Immunocompromised patients may require higher doses and longer duration of treatment, and treatment of acute infection is usually followed by long-term suppressive therapy
References
- 1. U.S. Centers for Disease Control. Cyclosporiasis. Retrieved from http://www.cdc.gov/parasites/cyclosporiasis/gen_info/faqs.html
- 2. RD Pearson. "Cyclosporiasis and Cystoisosporiasis". The Merck Manual. Retrieved from http://www.merckmanuals.com/professional/infectious-diseases/intestinal-protozoa/cyclosporiasis-and-cystoisosporiasis