Laxatives: Difference between revisions
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==Types== | ==Types== | ||
[[File:Diameters of the large intestine.png|thumb|Average inner diameters and ranges of different sections of the large intestine.<ref> Nguyen H, Loustaunau C, Facista A, Ramsey L, Hassounah N, Taylor H, et al. (July 2010). "Deficient Pms2, ERCC1, Ku86, CcOI in field defects during progression to colon cancer". Journal of Visualized Experiments (41). doi:10.3791/1931. PMC 3149991. PMID 20689513.</ref>]] | |||
===Bulk-forming agents=== | ===Bulk-forming agents=== | ||
''Substances, such as dietary fiber and hydrophilic agents that add bulk and water to more easily through the intestines.'' | ''Substances, such as dietary fiber and hydrophilic agents that add bulk and water to more easily through the intestines.'' | ||
*Site of action: Small and large intestines | *Site of action: Small and large intestines | ||
*Onset of action: 12–72 hours | *Onset of action: 12–72 hours | ||
*Examples: dietary fiber, [[psyllium]] (Metamucil), [[methylcellulose]] (Citrucel), [[polycarbophil]] (FiberCon) | *Examples: dietary fiber, [[Special:MyLanguage/psyllium|psyllium]] (Metamucil), [[Special:MyLanguage/methylcellulose|methylcellulose]] (Citrucel), [[Special:MyLanguage/polycarbophil|polycarbophil]] (FiberCon) | ||
====Dietary fiber==== | ====Dietary fiber==== | ||
Includes insoluble fiber and soluble fiber, such as: | Includes insoluble fiber and soluble fiber, such as: | ||
*Fruits, such as bananas, kiwifruits, prunes, apples (with skin), pears (with skin), and raspberries | *Fruits, such as bananas, kiwifruits, prunes, apples (with skin), pears (with skin), and raspberries | ||
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*Nuts | *Nuts | ||
*Legumes, such as beans, peas, and lentils | *Legumes, such as beans, peas, and lentils | ||
===Emollient agents (stool softeners)=== | ===Emollient agents (stool softeners)=== | ||
''Anionic surfactants that enable additional water and fats to be incorporated in the stool, making it easier for them to move through the gastrointestinal tract.'' | ''Anionic surfactants that enable additional water and fats to be incorporated in the stool, making it easier for them to move through the gastrointestinal tract.'' | ||
*Site of action: small and large intestines | *Site of action: small and large intestines | ||
*Onset of action: 12–72 hours | *Onset of action: 12–72 hours | ||
*Examples: [[docusate]] (Colace, Diocto), Gibs-Eze | *Examples: [[Special:MyLanguage/docusate|docusate]] (Colace, Diocto), Gibs-Eze | ||
===Lubricant agents=== | ===Lubricant agents=== | ||
''Coat the stool with slippery lipids and retard colonic absorption of water so that the stool slides through the colon more easily. Lubricant laxatives also increase the weight of stool and decrease intestinal transit time.'' | ''Coat the stool with slippery lipids and retard colonic absorption of water so that the stool slides through the colon more easily. Lubricant laxatives also increase the weight of stool and decrease intestinal transit time.'' | ||
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*Example: mineral oil | *Example: mineral oil | ||
===Hyperosmotic agents=== | |||
===Hyperosmotic agents=== | |||
''Substances that cause the intestines to hold more water within and create an osmotic effect that stimulates a bowel movement.'' | ''Substances that cause the intestines to hold more water within and create an osmotic effect that stimulates a bowel movement.'' | ||
*Site of action: colon | *Site of action: colon | ||
*Onset of Action: 12–72 hours (oral) 0.25 - 1 hour (rectal) | *Onset of Action: 12–72 hours (oral) 0.25 - 1 hour (rectal) | ||
*Examples: [[glycerin]] suppositories, [[sorbitol]], [[lactulose]], and [[ | *Examples: [[Special:MyLanguage/glycerin|glycerin]] suppositories, [[Special:MyLanguage/sorbitol|sorbitol]], [[Special:MyLanguage/lactulose|lactulose]], and [[Special:MyLanguage/Polyethylene glycol 3350|PEG]] (Colyte, MiraLax) | ||
===Saline laxative agents=== | ===Saline laxative agents=== | ||
''Non-absorbable osmotic substances that attract and retain water in the intestinal lumen, increasing intraluminal pressure that mechanically stimulates evacuation of the bowel. Magnesium-containing agents also cause the release of cholecystokinin, which increases intestinal motility and fluid secretion.'' | ''Non-absorbable osmotic substances that attract and retain water in the intestinal lumen, increasing intraluminal pressure that mechanically stimulates evacuation of the bowel. Magnesium-containing agents also cause the release of cholecystokinin, which increases intestinal motility and fluid secretion.'' | ||
*Site of action: small and large intestines | *Site of action: small and large intestines | ||
*Onset of action: 0.5–3 hours (oral), 2–15 minutes (rectal) | *Onset of action: 0.5–3 hours (oral), 2–15 minutes (rectal) | ||
*Examples: sodium phosphate (and variants), [[magnesium citrate]], [[magnesium hydroxide]] (milk of magnesia), and [[magnesium sulfate]] (Epsom salt) | *Examples: sodium phosphate (and variants), [[Special:MyLanguage/magnesium citrate|magnesium citrate]], [[Special:MyLanguage/magnesium hydroxide|magnesium hydroxide]] (milk of magnesia), and [[Special:MyLanguage/magnesium sulfate|magnesium sulfate]] (Epsom salt) | ||
===Stimulant agents=== | ===Stimulant agents=== | ||
''Act on the intestinal mucosa or nerve plexus, altering water and electrolyte secretion. They also stimulate peristaltic action and can be dangerous under certain circumstances.'' | ''Act on the intestinal mucosa or nerve plexus, altering water and electrolyte secretion. They also stimulate peristaltic action and can be dangerous under certain circumstances.'' | ||
*Site of action: colon | *Site of action: colon | ||
*Onset of action: 6–10 hours | *Onset of action: 6–10 hours | ||
*Examples: [[senna]] glycoside, [[bisacodyl]] | *Examples: [[Special:MyLanguage/senna|senna]] glycoside, [[Special:MyLanguage/bisacodyl|bisacodyl]] | ||
===Miscellaneous=== | ===Miscellaneous=== | ||
''Castor oil is a glyceride that is hydrolyzed by pancreatic lipase to ricinoleic acid, which produces laxative action by an unknown mechanism.'' | ''Castor oil is a glyceride that is hydrolyzed by pancreatic lipase to ricinoleic acid, which produces laxative action by an unknown mechanism.'' | ||
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*Onset of action: 2–6 hours | *Onset of action: 2–6 hours | ||
*Examples: castor oil | *Examples: castor oil | ||
==See Also== | ==See Also== | ||
*[[Constipation]] | |||
*[[Constipation (Peds)]] | *[[Special:MyLanguage/Constipation|Constipation]] | ||
*[[Special:MyLanguage/Constipation (Peds)|Constipation (Peds)]] | |||
==References== | ==References== | ||
<references/> | <references/> | ||
[[Category:Pharmacology]] | [[Category:Pharmacology]] | ||
[[Category:GI]] | [[Category:GI]] | ||
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Latest revision as of 23:16, 4 January 2026
Types
Average inner diameters and ranges of different sections of the large intestine.[1]
Bulk-forming agents
Substances, such as dietary fiber and hydrophilic agents that add bulk and water to more easily through the intestines.
- Site of action: Small and large intestines
- Onset of action: 12–72 hours
- Examples: dietary fiber, psyllium (Metamucil), methylcellulose (Citrucel), polycarbophil (FiberCon)
Dietary fiber
Includes insoluble fiber and soluble fiber, such as:
- Fruits, such as bananas, kiwifruits, prunes, apples (with skin), pears (with skin), and raspberries
- Vegetables, such as broccoli, string beans, kale, spinach, cooked winter squash, cooked green peas, and baked potatoes (with skin)
- Whole grains
- Bran products
- Nuts
- Legumes, such as beans, peas, and lentils
Emollient agents (stool softeners)
Anionic surfactants that enable additional water and fats to be incorporated in the stool, making it easier for them to move through the gastrointestinal tract.
- Site of action: small and large intestines
- Onset of action: 12–72 hours
- Examples: docusate (Colace, Diocto), Gibs-Eze
Lubricant agents
Coat the stool with slippery lipids and retard colonic absorption of water so that the stool slides through the colon more easily. Lubricant laxatives also increase the weight of stool and decrease intestinal transit time.
- Site of action: colon
- Onset of action: 6–8 hours
- Example: mineral oil
Hyperosmotic agents
Substances that cause the intestines to hold more water within and create an osmotic effect that stimulates a bowel movement.
- Site of action: colon
- Onset of Action: 12–72 hours (oral) 0.25 - 1 hour (rectal)
- Examples: glycerin suppositories, sorbitol, lactulose, and PEG (Colyte, MiraLax)
Saline laxative agents
Non-absorbable osmotic substances that attract and retain water in the intestinal lumen, increasing intraluminal pressure that mechanically stimulates evacuation of the bowel. Magnesium-containing agents also cause the release of cholecystokinin, which increases intestinal motility and fluid secretion.
- Site of action: small and large intestines
- Onset of action: 0.5–3 hours (oral), 2–15 minutes (rectal)
- Examples: sodium phosphate (and variants), magnesium citrate, magnesium hydroxide (milk of magnesia), and magnesium sulfate (Epsom salt)
Stimulant agents
Act on the intestinal mucosa or nerve plexus, altering water and electrolyte secretion. They also stimulate peristaltic action and can be dangerous under certain circumstances.
Miscellaneous
Castor oil is a glyceride that is hydrolyzed by pancreatic lipase to ricinoleic acid, which produces laxative action by an unknown mechanism.
- Site of action: colon
- Onset of action: 2–6 hours
- Examples: castor oil
See Also
References
- ↑ Nguyen H, Loustaunau C, Facista A, Ramsey L, Hassounah N, Taylor H, et al. (July 2010). "Deficient Pms2, ERCC1, Ku86, CcOI in field defects during progression to colon cancer". Journal of Visualized Experiments (41). doi:10.3791/1931. PMC 3149991. PMID 20689513.