Renal disease induced coagulopathy: Difference between revisions

(Created page with "==Background== *Uremic toxins inhibit platelet aggregation *Dialysis filter may cause thrombocytopenia ==Treatment== #Acute dialysis ##pRBCs ###Raising hct to above 25-30% im...")
 
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==Background==
#REDIRECT[[Uremic bleeding syndrome]]
*Uremic toxins inhibit platelet aggregation
*Dialysis filter may cause thrombocytopenia
 
==Treatment==
#Acute dialysis
##pRBCs
###Raising hct to above 25-30% improves bleeding time
##Desmopressin
###Simplest and least toxic acute treatment
###Increases release of factor VIII:von Willebrand factor multimers
###0.3 mg/kg IV (preferred) or SC (max 20mg)
###Onset of action ~1hr, duration of action ~4-24hr
#Estrogen
##Unclear mechanism of action
##Onset of action within 1d
##Options
###Conjugated estrogen 0.6mg/kg IV or 2.5-25mg PO daily
#Cryoprecipitate
##Only indicated for life-threatening bleeding resistant to DDAVP and blood tranfusion
#Plt transfusion
##Minimally effective b/c infused plts quickly acquire the uremic defect
 
==See Also==
*[[Coagulopathy (Main)]]
 
==Source==
*Tintinalli
*UpToDate
 
[[Category:Heme/Onc]]

Latest revision as of 11:47, 8 November 2015

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