Miconazole: Difference between revisions

Latest revision as of 12:34, 20 March 2026

Administration

Type: Antifungal
Dosage Forms: 2% Cream
Routes of Administration: Topical
Common Trade Names: Monistat-Derm, Desenex, Lotrimin, Micatin, Zeasorb

Adult Dosing

Indications by Disease

Disease	Dose	Context
Candida vulvovaginitis	2% cream applied vaginally for 7 days OR 4% cream x 3 days	Intravaginal therapy
Candidiasis	2% cream applied topically BID x 2 weeks	Cutaneous candidiasis
Tinea corporis	2% cream applied topically BID x 4 weeks	Mild disease
Tinea cruris	2% cream applied topically BID x 2 weeks	Topical antifungal
Tinea pedis	2% cream applied topically BID x 4 weeks	Topical antifungal

Pediatric Dosing

Same as adult

Indications by Disease

Special Populations

Pregnancy Rating

Risk of fetal harm not expected
May use during pregnancy

Lactation risk

May use while breastfeeding

Renal Dosing

Adult: No adjustment needed
Pediatric: No adjustment needed

Hepatic Dosing

Adult: No adjustment needed
Pediatric: No adjustment needed

Contraindications

Allergy to class/drug

Adverse Reactions

Serious

Anaphylaxis (rare)

Common

Skin irritation
Burning
Pruritus

Pharmacology

Metabolism: Hepatic
Info: Minimal systemic absorption from topical use

Mechanism of Action

Azole antifungal
- Inhibits ergosterol synthesis in fungal cell membranes

References

Authors:

@@ Line 6: / Line 6: @@
 ==Adult Dosing==
-===[[Candidiasis]], cutaneous===
+===Indications by Disease===
-*Apply 2% Cream BID to affected area x2 weeks
+{{#ask: [[Has DrugName::Miconazole]] [[Has Population::Adult]]
-===[[Tinea corporis]]===
+ |?Treats disease=Disease
-*Apply 2% Cream BID to affected area x4 weeks
+ |?Has Dose=Dose
-===[[Tinea cruris]]===
+ |?Has Context=Context
-*Apply 2% Cream BID to affected area x2 weeks
+ |format=table
-===[[Tinea pedis]]===
+ |limit=50
-*Apply 2% Cream BID to affected area x4 weeks
+ |mainlabel=-
+ |headers=show
+ |sort=Treats disease
+}}
 ==Pediatric Dosing==
-===[[Candidiasis]], cutaneous===
+Same as adult
-*Apply 2% Cream BID to affected area x2 weeks
-===[[Tinea corporis]]===
+===Indications by Disease===
-*Apply 2% Cream BID to affected area x4 weeks
+{{#ask: [[Has DrugName::Miconazole]] [[Has Population::Pediatric]]
-===[[Tinea cruris]]===
+ |?Treats disease=Disease
-*Apply 2% Cream BID to affected area x2 weeks
+ |?Has Dose=Dose
-===[[Tinea pedis]]===
+ |?Has Context=Context
-*Apply 2% Cream BID to affected area x4 weeks
+ |format=table
+ |limit=50
+ |mainlabel=-
+ |headers=show
+ |sort=Treats disease
+}}
 ==Special Populations==
 ===[[Drug pregnancy categories|Pregnancy Rating]]===
-*Risk of fetal harm no expected
+*Risk of fetal harm not expected
 *May use during pregnancy
 ===Lactation risk===
 *May use while breastfeeding
 ===Renal Dosing===
-*Adult: Not defined
+*Adult: No adjustment needed
-*Pediatric: Not defined
+*Pediatric: No adjustment needed
 ===Hepatic Dosing===
-*Adult: Not defined
+*Adult: No adjustment needed
-*Pediatric: Not defined
+*Pediatric: No adjustment needed
 ==Contraindications==
@@ Line 46: / Line 51: @@
 ==Adverse Reactions==
 ===Serious===
-*May occur, but none reported
+*[[Anaphylaxis]] (rare)
 ===Common===
-*Irritation, burning, stining
+*Skin irritation
-*[[Pruritus]], erythema, maceration
+*Burning
-*[[Contact dermatitis]]
+*Pruritus
 ==Pharmacology==
-*Half-life: Unknown
+*Metabolism: Hepatic
-*Metabolism: None, minimal systemic absorption
+*Info: Minimal systemic absorption from topical use
-*Excretion: None
 ==Mechanism of Action==
-*Inhibits 14-alpha demethylase, reducing fungal cell membrane ergosterol synthesis
+*Azole antifungal
+**Inhibits ergosterol synthesis in fungal cell membranes
-==Comments==
 ==See Also==
+*[[Antifungals]]
+*[[Candidiasis]]
+*[[Tinea corporis]]
 ==References==
@@ Line 71: / Line 74: @@
 [[Category:Pharmacology]]
+[[Category:ID]]