Ecallantide: Difference between revisions
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==Comments== | ==Comments== | ||
*Plasma kallikrein works as cofactor to formation of bradykinin which is implicated in angioedema | *Plasma kallikrein works as cofactor to formation of bradykinin which is implicated in angioedema | ||
==Indications by Condition== | |||
''The following table is automatically generated from disease/condition pages across WikEM.'' | |||
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|?Has Dose=Dose | |||
|?Has Context=Context | |||
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|?Has Population=Population | |||
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==See Also== | ==See Also== | ||
*[[Angioedema (Upper Airway)]] | *[[Angioedema (Upper Airway)]] | ||
Latest revision as of 21:56, 20 March 2026
General
- Type: Kallikrein inhibitor for angioedema
- Dosage Forms: 30mg
- Routes of Administration: SQ
- Common Trade Names: Kalbitor
Adult Dosing
Acute hereditary angioedema
- 30mg SQ
- Max 60mg/ 24 hr
Pediatric Dosing
Acute hereditary angioedema (>12yo)
- 30mg SQ
Special Populations
- Pregnancy Rating:C
- Lactation risk:Safety Unknown
- Renal Dosing
- Hepatic Dosing
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- anaphylaxis
- hypersensitivity reaction
Common
- headache
- nausea
- fatigue
- diarrhea
- URI
- injection site reaction
- nasopharyngitis
- vomiting
- pruritus
- abdominal pain
- fever
- anaphylaxis
Pharmacology
- Half-life: 2h
- Metabolism: CYP450
- Excretion: Urine
- Mechanism of Action: selectively, reversibly inhibits plasma kallikrein, preventing bradykinin generation
Comments
- Plasma kallikrein works as cofactor to formation of bradykinin which is implicated in angioedema
Indications by Condition
The following table is automatically generated from disease/condition pages across WikEM.
| Indication | Dose | Context | Route | Population |
|---|---|---|---|---|
| Angioedema | 10 mg SC x3 at different sites (30 mg total) | Kallikrein inhibitor (HAE) | SC | Adult |