Labetalol: Difference between revisions
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*Onset of action = 2-5min (IV) | *Onset of action = 2-5min (IV) | ||
*Duration of action = 2-4hr (IV) | *Duration of action = 2-4hr (IV) | ||
==Indications by Condition== | |||
''The following table is automatically generated from disease/condition pages across WikEM.'' | |||
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|?Has Dose=Dose | |||
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==See Also== | ==See Also== | ||
Latest revision as of 21:55, 20 March 2026
General
- Type: Beta blockers
- Dosage Forms:
- Common Trade Names:
Adult Dosing
- Bolus dosing
- 20mg IV followed by 40-80mg q10min up to total of 300mg
- Infusion dosing
- 0.5-2mg/min
Intracranial hemorrhage
- Start with labetalol 20mg over 1-2 minutes
- Then, 20mg q3-5 mins until target blood pressure is achieved
- Then, start an infusion of 1-8mg/min
Pediatric Dosing
Special Populations
- Pregnancy Rating: C
- Lactation: Compatible with breastfeeding
- Renal Dosing
- Adult
- No renal dosing adjustments necessary. Drug not removed with hemodialysis
- Pediatric
- No renal dosing adjustments necessary. Drug not removed with hemodialysis
- Adult
- Hepatic Dosing
- Adult
- May need reduced dosing given decreased metabolism and increased oral bioavailability with hepatic impairment however no specific dosing adjustments in manufacturer labeling. Use caution.
- Pediatric
- May need reduced dosing given decreased metabolism and increased oral bioavailability with hepatic impairment however no specific dosing adjustments in manufacturer labeling. Use caution.
- Adult
Indications
- hypertension in setting of myocardial ischemia
- hypertension in setting of neurologic injury
- hypertension in setting of preeclampsia/eclampsia
Contraindications
- Allergy to class/drug
Adverse Reactions
- Orthostatic hypotension
Pharmacology
- Half-life: 5-8hrs
- Metabolism: Hepatic via conjugation
- Excretion: Renal 55-60%
- Mechanism of Action:
- Class II - Nonselective β-blocker
- α1-blocker
- Onset of action = 2-5min (IV)
- Duration of action = 2-4hr (IV)
Indications by Condition
The following table is automatically generated from disease/condition pages across WikEM.
| Indication | Dose | Context | Route | Population |
|---|---|---|---|---|
| Hypertensive emergency | 20 mg IV bolus, double q10 min (max 300 mg) or 0.5-2 mg/min drip | 1st line antihypertensive | IV | Adult |
| Intracranial hemorrhage (main) | 20 mg IV bolus, repeat q3-5 min; then 1-8 mg/min drip | BP control in ICH | IV | Adult |
| Nontraumatic thoracic aortic dissection | 20mg bolus, then 40-80mg q10min (max 300mg) or 1-2mg/min drip | Heart rate and blood pressure control | IV | Adult |
| Stroke (main) | 10-20 mg IV push, may repeat x1 | BP control in acute stroke | IV | Adult |
| Traumatic intracerebral hemorrhage | 20 mg IV bolus, repeat q3-5 min; then 1-8 mg/min drip | BP control in ICH | IV | Adult |
See Also
References
Labetalol: Drug information. UpToDate. www.uptodate.com. Accessed April 2, 2019.