Hydrocortisone topical: Difference between revisions

Latest revision as of 21:56, 20 March 2026

General

Type: Topical steroid
Dosage Forms: 0.5%, 1%, 2.5% crm, lotion, oint
Common Trade Names: Cortizone, Cortaid, Hytone, Texacort

Adult Dosing

Dermatoses, steroid-responsive

Apply bid-QID

Pediatric Dosing

Dermatoses, steroid-responsive

Apply bid-QID

Special Populations

Pregnancy Rating: C
Lactation: Excretion in milk unknown; use with caution
Renal Dosing: None
Hepatic Dosing: None

Contraindications

Allergy to class/drug
caution if skin infection
caution in pediatric patients

Adverse Reactions

Serious

HPA axis suppresion
Cushing syndrome
hyperglycemia
intracranial hypertension (pediatric patients)

Common

burning
pruritus
irritation
dryness
folliculitis
hypertrichosis
acneiform dermatitis
hypopigmentation
perioral dermatitis
allergic contact dermatitis
maceration
secondary infection
skin atrophy
striae
miliaria

Pharmacology

Half-life: 8-12h
Metabolism: liver primarily; CYP450
Excretion: urine
Mechanism of Action: exact mechanim of anti-inflammatory action unknown; inhibits multiple inflammatory cytokines; produces multiple gluocorticoid and mineralocorticoid effects

Indications by Condition

The following table is automatically generated from disease/condition pages across WikEM.

Indication	Dose	Context	Route	Population
COPD exacerbation	100-125 mg IV q6h x5 days	Corticosteroid (IV option)	IV	Adult
Pituitary apoplexy	100-200mg IV bolus, then 2-4mg/hr infusion	Stress-dose corticosteroid replacement	IV	Adult
Sepsis (main)	50 mg IV q6h (200 mg/day)	Stress dose steroids for septic shock	IV	Adult
Thyroid storm	300 mg IV bolus, then 100 mg IV TID	Adrenal insufficiency treatment + T4→T3 blockade	IV	Adult
Toxic megacolon	100mg q6hr	Anti-inflammatory for underlying IBD	IV	Adult

References

Authors:

@@ Line 1: / Line 1: @@
 ==General==
-*Type:
+*Type: [[Topical steroid]]
-*Dosage Forms:
+*Dosage Forms: 0.5%, 1%, 2.5% crm, lotion, oint
-*Common Trade Names:
+*Common Trade Names: Cortizone, Cortaid, Hytone, Texacort
 ==Adult Dosing==
+===Dermatoses, steroid-responsive===
+*Apply bid-QID
 ==Pediatric Dosing==
+===Dermatoses, steroid-responsive===
+*Apply bid-QID
 ==Special Populations==
-*[[Drug Ratings in Pregnancy|Pregnancy Rating]]:
+*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C
-*Lactation:
+*Lactation: Excretion in milk unknown; use with caution
-*Renal Dosing
+*Renal Dosing: None
-**Adult
+*Hepatic Dosing: None
-**Pediatric
-*Hepatic Dosing
-**Adult
-**Pediatric
 ==Contraindications==
 *Allergy to class/drug
+*caution if skin infection
+*caution in pediatric patients
 ==Adverse Reactions==
 ===Serious===
+*HPA axis suppresion
+*Cushing syndrome
+*hyperglycemia
+*intracranial hypertension (pediatric patients)
 ===Common===
+*burning
+*pruritus
+*irritation
+*dryness
+*folliculitis
+*hypertrichosis
+*acneiform dermatitis
+*hypopigmentation
+*perioral dermatitis
+*allergic contact dermatitis
+*maceration
+*secondary infection
+*skin atrophy
+*striae
+*miliaria
 ==Pharmacology==
-*Half-life:
+*Half-life: 8-12h
-*Metabolism:
+*Metabolism: liver primarily; CYP450
-*Excretion:
+*Excretion: urine
-*Mechanism of Action:
+*Mechanism of Action: exact mechanim of anti-inflammatory action unknown; inhibits multiple inflammatory cytokines; produces multiple gluocorticoid and mineralocorticoid effects
+==Indications by Condition==
+''The following table is automatically generated from disease/condition pages across WikEM.''
+{{#ask:[[Has DrugName::Hydrocortisone]]
+ |?Has Indication=Indication
+ |?Has Dose=Dose
+ |?Has Context=Context
+ |?Has Route=Route
+ |?Has Population=Population
+ |format=table
+ |headers=plain
+ |mainlabel=-
+ |sort=Has Indication
+ |limit=50
+}}
 ==See Also==
+*[[Stress dose steroids]]
+*[[Hydrocortisone (systemic)]]
-==Sources==
+==References==
+<references/>
-<references/>
+[[Category:Pharmacology]]
-[[Category:Drugs]]
+[[Category:Dermatology]]