Template:Septic Arthritis Antibiotics: Difference between revisions

Latest revision as of 12:55, 20 March 2026

For adults treatment should be divided into Gonococcal and Non-Gonococcal

Gonococcal

Ceftriaxone 1g IV once daily
Cefixime 400 mg PO BID is an option for outpatient therapy after initial 3 days of Ceftriaxone

Non-Gonococcal

Treatment should cover S. aureus, Streptococcus, Pseudomonas, Enterococcus, B. burgdorferi
Vancomycin 15-20 mg/kg IV BID PLUS any of the following:
- Ceftriaxone 2g IV once daily
- Cefepime 2g IV three times daily
- Ceftazidime 2g IV three times daily
- Ciprofloxacin 400mg IV three times daily

Pediatrics

Neonates (<3 months)

Nafcillin 50mg/kg IV q6hrs + Cefotaxime 50mg/kg IV q8hrs

Children (>3 months)

Ceftriaxone 50-75mg/kg IV daily (max 2g) OR
Cefazolin 25mg/kg IV q8hrs (max 2g/dose)
If MRSA suspected: Vancomycin 15mg/kg IV q6hrs OR Clindamycin 10-13mg/kg IV q8hrs (max 900mg/dose)

Sickle Cell

Coverage for Salmonella and Staphylococcus spp

Vancomycin 20mg/kg IV twice daily PLUS
- Ciprofloxacin 400mg IV three times daily OR
- Imipenem/Cilastatin 1g IV three times daily

@@ Line 1: / Line 1: @@
 ''For adults treatment should be divided into Gonococcal and Non-Gonococcal
 ====[[Gonococcal]]====
-*[[Ceftriaxone]] 1g IV once daily
+*{{AntibioticDose|disease=Septic arthritis|drug=Ceftriaxone|dose=1g IV once daily|context=Gonococcal}}
-*[[Cefixime]] 400 mg PO BID is an option for outpatient therapy after initial 3 days of [[Ceftriaxone]]
+*{{AntibioticDose|disease=Septic arthritis|drug=Cefixime|dose=400 mg PO BID|context=Gonococcal, Outpatient}} is an option for outpatient therapy after initial 3 days of [[Ceftriaxone]]
 ====Non-Gonococcal====
 *Treatment should cover [[S. aureus]], [[Streptococcus]], [[Pseudomonas]], [[Enterococcus]], [[ Borrelia burgdorferi| B. burgdorferi]]
-*Vancomycin 15-20 mg/kg IV BID PLUS any of the following:
+*{{AntibioticDose|disease=Septic arthritis|drug=Vancomycin|dose=15-20 mg/kg IV BID|context=Non-Gonococcal}} PLUS any of the following:
-**[[Ceftriaxone]] 2g IV once daily
+**{{AntibioticDose|disease=Septic arthritis|drug=Ceftriaxone|dose=2g IV once daily|context=Non-Gonococcal}}
-**[[Cefepime]] 2g IV three times daily
+**{{AntibioticDose|disease=Septic arthritis|drug=Cefepime|dose=2g IV three times daily|context=Non-Gonococcal}}
-**[[Ceftazidime]] 2g IV three times daily
+**{{AntibioticDose|disease=Septic arthritis|drug=Ceftazidime|dose=2g IV three times daily|context=Non-Gonococcal}}
-**[[Ciprofloxacin]] 400mg IV three times daily
+**{{AntibioticDose|disease=Septic arthritis|drug=Ciprofloxacin|dose=400mg IV three times daily|context=Non-Gonococcal}}
 ====Pediatrics====
-*[[Ceftriaxone]] 1g IV once daily
+=====Neonates (<3 months)=====
+*{{AntibioticDose|disease=Septic arthritis|drug=Nafcillin|dose=50mg/kg IV q6hrs|context=Pediatric Neonate|population=Pediatric}} + {{AntibioticDose|disease=Septic arthritis|drug=Cefotaxime|dose=50mg/kg IV q8hrs|context=Pediatric Neonate|population=Pediatric}}
+=====Children (>3 months)=====
+*{{AntibioticDose|disease=Septic arthritis|drug=Ceftriaxone|dose=50-75mg/kg IV daily (max 2g)|context=Pediatric >3mo|population=Pediatric}} '''OR'''
+*{{AntibioticDose|disease=Septic arthritis|drug=Cefazolin|dose=25mg/kg IV q8hrs (max 2g/dose)|context=Pediatric >3mo|population=Pediatric}}
+*If MRSA suspected: {{AntibioticDose|disease=Septic arthritis|drug=Vancomycin|dose=15mg/kg IV q6hrs|context=Pediatric MRSA|population=Pediatric}} '''OR''' {{AntibioticDose|disease=Septic arthritis|drug=Clindamycin|dose=10-13mg/kg IV q8hrs (max 900mg/dose)|context=Pediatric MRSA|population=Pediatric}}
+====[[Sickle Cell]]====
+''Coverage for [[Salmonella]] and [[Staphylococcus]] spp''
+*{{AntibioticDose|disease=Septic arthritis|drug=Vancomycin|dose=20mg/kg IV twice daily|context=Sickle Cell}} PLUS
+**{{AntibioticDose|disease=Septic arthritis|drug=Ciprofloxacin|dose=400mg IV three times daily|context=Sickle Cell}} OR
+**{{AntibioticDose|disease=Septic arthritis|drug=Imipenem/Cilastatin|dose=1g IV three times daily|context=Sickle Cell}}