Template:Pertussis Antibiotics: Difference between revisions
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(Add pediatric Clarithromycin and Erythromycin dosing) |
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*A reasonable guideline is to treat persons aged >1 year within 3 weeks of cough onset and infants aged <1 year and pregnant women (especially near term) within 6 weeks of cough onset. <ref>CDC - Pertussis http://www.cdc.gov/pertussis/clinical/treatment.html</ref> | *A reasonable guideline is to treat persons aged >1 year within 3 weeks of cough onset and infants aged <1 year and pregnant women (especially near term) within 6 weeks of cough onset. <ref>CDC - Pertussis http://www.cdc.gov/pertussis/clinical/treatment.html</ref> | ||
*TMP--SMZ should not be administered to pregnant women, nursing mothers, or infants aged <2 months.<ref> CDC MMWR Pertusis http://www.cdc.gov/mmwr/preview/mmwrhtml/rr5414a1.htm</ref> | *TMP--SMZ should not be administered to pregnant women, nursing mothers, or infants aged <2 months.<ref> CDC MMWR Pertusis http://www.cdc.gov/mmwr/preview/mmwrhtml/rr5414a1.htm</ref> | ||
*The following regemins are for active disease or | *The following regemins are for active disease or postexposure prophylaxis. If a patient is has confirmed disease and is likely to be in contact with infants or pregnant women then the patient should be treated as up to 6-8 weeks after the onset of their illness. | ||
====< 1 month old==== | ====< 1 month old==== | ||
''Same antibiotics for active disease and postexposure prophylaxis'' | ''Same antibiotics for active disease and postexposure prophylaxis'' | ||
* | *{{AntibioticDose|disease=Pertussis|drug=Azithromycin|dose=10mg/kg (max 500mg/day) daily x 5 days|context=<1 month old|population=Pediatric}} | ||
====>1 month old==== | ====>1 month old==== | ||
* | *{{AntibioticDose|disease=Pertussis|drug=Azithromycin|dose=10mg/kg (max 500mg/day) daily x 5 days|context=>1 month old|population=Pediatric}} | ||
**if > 6 months old then day 2-5 of treatment should be reduced to 5mg/kg (250mg/day max) | **if > 6 months old then day 2-5 of treatment should be reduced to 5mg/kg (250mg/day max) | ||
* | *{{AntibioticDose|disease=Pertussis|drug=TMP/SMX|dose=4mg/kg PO BID daily for 14 days|context=>1 month old (if >2mo)|population=Pediatric}} (if > 2 months old) | ||
*{{AntibioticDose|disease=Pertussis|drug=Clarithromycin|dose=>6 months: 7.5mg/kg PO BID x 7 days (max 500mg/dose)|context=>1 month old|population=Pediatric}} | |||
*{{AntibioticDose|disease=Pertussis|drug=Erythromycin|dose=10mg/kg PO QID x 14 days (max 2g/day)|context=>1 month old|population=Pediatric}} | |||
====Adults==== | ====Adults==== | ||
'' | ''any of the following antibiotics are acceptable although azithromycin is most commonly prescribed'' | ||
* | *{{AntibioticDose|disease=Pertussis|drug=Azithromycin|dose=500mg PO once daily for day #1 then 250mg PO once daily for days #2-5|context=Adults}} | ||
* | *{{AntibioticDose|disease=Pertussis|drug=Clarithromycin|dose=500mg BID x7 days|context=Adults}} | ||
* | *{{AntibioticDose|disease=Pertussis|drug=Erythromycin|dose=500mg QID x7 days|context=Adults}} | ||
Latest revision as of 13:04, 20 March 2026
- Antibiotics do not help with severity or duration but may decrease infectivity.
- A reasonable guideline is to treat persons aged >1 year within 3 weeks of cough onset and infants aged <1 year and pregnant women (especially near term) within 6 weeks of cough onset. [1]
- TMP--SMZ should not be administered to pregnant women, nursing mothers, or infants aged <2 months.[2]
- The following regemins are for active disease or postexposure prophylaxis. If a patient is has confirmed disease and is likely to be in contact with infants or pregnant women then the patient should be treated as up to 6-8 weeks after the onset of their illness.
< 1 month old
Same antibiotics for active disease and postexposure prophylaxis
- Azithromycin 10mg/kg (max 500mg/day) daily x 5 days
>1 month old
- Azithromycin 10mg/kg (max 500mg/day) daily x 5 days
- if > 6 months old then day 2-5 of treatment should be reduced to 5mg/kg (250mg/day max)
- TMP/SMX 4mg/kg PO BID daily for 14 days (if > 2 months old)
- Clarithromycin >6 months: 7.5mg/kg PO BID x 7 days (max 500mg/dose)
- Erythromycin 10mg/kg PO QID x 14 days (max 2g/day)
Adults
any of the following antibiotics are acceptable although azithromycin is most commonly prescribed
- Azithromycin 500mg PO once daily for day #1 then 250mg PO once daily for days #2-5
- Clarithromycin 500mg BID x7 days
- Erythromycin 500mg QID x7 days
- ↑ CDC - Pertussis http://www.cdc.gov/pertussis/clinical/treatment.html
- ↑ CDC MMWR Pertusis http://www.cdc.gov/mmwr/preview/mmwrhtml/rr5414a1.htm