Template:Peritonitis Antibiotics: Difference between revisions

Latest revision as of 13:20, 20 March 2026

Intra-Abdominal Sepsis/Peritonitis

	Harbor-UCLA	Santa Monica-UCLA	Other
Primary	Metronidazole 500mg IV q8hrs Plus one of the following: Ceftriaxone 1g IV once daily Ciprofloxacin 400mg IV q12hrs Cefazolin 1g (30mg/kg) IV q8hrs Levofloxacin 750mg IV once daily	Metronidazole 500mg IV q8h + Vancomycin 15mg/kg/dose IV q12h (Max dose = 1500mg) Plus one of the following: Piperacillin/tazobactam 4.5g IV q6h Ertapenem 1g IV q24h Ceftriaxone 1g IV q24h	One of the following: Piperacillin-tazobactam Ticarcillin-clavulanate 3.1 g IV every 6 hours Ertapenem 1 g every 24 hours Moxifloxacin 400 mg IV every 24 hours
Allergy or prior exposure	Piperacillin/Tazobactam 4.5g (80mg/kg) IV q8hrs OR Metronidazole 500mg IV q8hrs PLUS Cefepime 2g IV once daily OR Ciprofloxacin 400mg IV q12hrs OR Levofloxacin 750mg IV once daily Meropenem 1g (20mg/kg) IV q8hrs OR Doripenem 500mg IV q8hrs OR Aztreonam 2g (30mg/kg) IV q8hrs + Metronidazole 500mg IV q8hrs	aztreonam 2g IV q8h + metronidazole 500mg IV q8h +/- vancomycin 15mg/kg/dose IV q12h (Max dose = 1500mg)

Pediatric

Metronidazole 7.5mg/kg IV q8hrs (max 500mg) + one of:
- Ceftriaxone 50-75mg/kg IV daily (max 2g) OR
- Cefotaxime 50mg/kg IV q8hrs (max 2g/dose)
Piperacillin/Tazobactam 80-100mg/kg IV q6-8hrs (max 4.5g) OR
Meropenem 20mg/kg IV q8hrs (max 1g)

@@ Line 1: / Line 1: @@
-====Moderate====
+===Intra-Abdominal Sepsis/[[Peritonitis]]===
-*[[Metronidazole]] 500mg IV q8hrs PLUS
+{| {{table}}
-**[[Ceftriaxone]] 1g IV once daily OR
+| align="center" style="background:#f0f0f0;"|'''''
-**[[Ciprofloxacin]] 400mg IV q12hrs OR
+| align="center" style="background:#f0f0f0;"|'''Harbor-UCLA'''
-**[[Cefazolin]] 1g (30mg/kg) IV q8hrs OR
+| align="center" style="background:#f0f0f0;"|'''Santa Monica-UCLA'''
-**[[Levofloxacin]] 750mg IV once daily
+| align="center" style="background:#f0f0f0;"|'''Other'''
+|-
+| Primary||
+*{{AntibioticDose|disease=Peritonitis|drug=Metronidazole|dose=500mg IV q8hrs|context=Primary}}
+*Plus one of the following:
+**{{AntibioticDose|disease=Peritonitis|drug=Ceftriaxone|dose=1g IV once daily|context=Primary}}
+**{{AntibioticDose|disease=Peritonitis|drug=Ciprofloxacin|dose=400mg IV q12hrs|context=Primary}}
+**{{AntibioticDose|disease=Peritonitis|drug=Cefazolin|dose=1g (30mg/kg) IV q8hrs|context=Primary}}
+**{{AntibioticDose|disease=Peritonitis|drug=Levofloxacin|dose=750mg IV once daily|context=Primary}}
+||
+*[[Metronidazole]] 500mg IV q8h
+*+ [[Vancomycin]] 15mg/kg/dose IV q12h (Max dose = 1500mg)
+*Plus one of the following:
+**[[Piperacillin/tazobactam]] 4.5g IV q6h
+**[[Ertapenem]] 1g IV q24h
+**[[Ceftriaxone]] 1g IV q24h
+||
+*One of the following:
+**[[Piperacillin-tazobactam]]
+**[[Ticarcillin-clavulanate]] 3.1 g IV every 6 hours
+**{{AntibioticDose|disease=Peritonitis|drug=Ertapenem|dose=1 g every 24 hours|context=Primary}}
+**{{AntibioticDose|disease=Peritonitis|drug=Moxifloxacin|dose=400 mg IV every 24 hours|context=Primary}}
+|-
+| Allergy or prior exposure ||
+*{{AntibioticDose|disease=Peritonitis|drug=Piperacillin/Tazobactam|dose=4.5g (80mg/kg) IV q8hrs|context=Allergy/Prior exposure}} OR
+*{{AntibioticDose|disease=Peritonitis|drug=Metronidazole|dose=500mg IV q8hrs|context=Allergy/Prior exposure}} PLUS
+**{{AntibioticDose|disease=Peritonitis|drug=Cefepime|dose=2g IV once daily|context=Allergy/Prior exposure}} OR
+**{{AntibioticDose|disease=Peritonitis|drug=Ciprofloxacin|dose=400mg IV q12hrs|context=Allergy/Prior exposure}} OR
+**{{AntibioticDose|disease=Peritonitis|drug=Levofloxacin|dose=750mg IV once daily|context=Allergy/Prior exposure}}
+*{{AntibioticDose|disease=Peritonitis|drug=Meropenem|dose=1g (20mg/kg) IV q8hrs|context=Allergy/Prior exposure}} OR
+*{{AntibioticDose|disease=Peritonitis|drug=Doripenem|dose=500mg IV q8hrs|context=Allergy/Prior exposure}} OR
+*{{AntibioticDose|disease=Peritonitis|drug=Aztreonam|dose=2g (30mg/kg) IV q8hrs|context=Allergy/Prior exposure}} + [[Metronidazole]] 500mg IV q8hrs
+||
+*[[aztreonam]] 2g IV q8h
+*+ [[metronidazole]] 500mg IV q8h
+*+/- [[vancomycin]] 15mg/kg/dose IV q12h (Max dose = 1500mg)
+||
+|}
-====Severe====
+===Pediatric===
-*[[Piperacillin/Tazobactam]] 4.5g (80mg/kg) IV q8hrs OR
+*{{AntibioticDose|disease=Peritonitis|drug=Metronidazole|dose=7.5mg/kg IV q8hrs (max 500mg)|context=Pediatric|population=Pediatric}} + one of:
-*[[Metronidazole]] 500mg IV q8hrs PLUS
+**{{AntibioticDose|disease=Peritonitis|drug=Ceftriaxone|dose=50-75mg/kg IV daily (max 2g)|context=Pediatric|population=Pediatric}} '''OR'''
-**[[Cefepime]] 2g IV once daily OR
+**{{AntibioticDose|disease=Peritonitis|drug=Cefotaxime|dose=50mg/kg IV q8hrs (max 2g/dose)|context=Pediatric|population=Pediatric}}
-**[[Ciprofloxacin]] 400mg IV q12hrs OR
+*{{AntibioticDose|disease=Peritonitis|drug=Piperacillin/Tazobactam|dose=80-100mg/kg IV q6-8hrs (max 4.5g)|context=Pediatric|population=Pediatric}} '''OR'''
-**[[Levofloxacin]] 750mg IV once daily
+*{{AntibioticDose|disease=Peritonitis|drug=Meropenem|dose=20mg/kg IV q8hrs (max 1g)|context=Pediatric|population=Pediatric}}
-*[[Meropenem]] 1g (20mg/kg) IV q8hrs OR
-*[[Doripenem]] 500mg IV q8hrs OR
-*[[Aztreonam]] 2g (30mg/kg) IV q8hrs + [[Metronidazole]] 500mg IV q8hrs