Praziquantel: Difference between revisions
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==Administration== | ==Administration== | ||
*Type: [[Antiparasitic]], anthelmintic | *Type: [[Antiparasitic]], anthelmintic<ref>Cioli D, et al. Schistosomiasis control: praziquantel forever? Mol Biochem Parasitol. 2014;195(1):23-29. PMID 24955523</ref> | ||
*Dosage Forms: 600 | *Dosage Forms: 600 | ||
*Routes of Administration: Oral | *Routes of Administration: Oral | ||
| Line 6: | Line 6: | ||
==Adult Dosing== | ==Adult Dosing== | ||
*Schistosomiasis: 20mg/kg PO tid x1 day | |||
**Separate doses by 4-6h | |||
**Give with food | |||
**Do not crush/chew | |||
*Liver flukes: 25mg/kg PO tid x1 day | |||
**Separate doses by 4-6h | |||
*Cysticercosis: 50mg/kg/day PO divided q8h x14 days | |||
**Off label use | |||
*Tapeworms: 5-25mg/kg PO x1 | |||
**Off label use | |||
===Indications by Disease=== | ===Indications by Disease=== | ||
{{#ask: [[Has DrugName::Praziquantel]] [[Has Population::Adult]] | {{#ask: [[Has DrugName::Praziquantel]] [[Has Population::Adult]] | ||
|?Treats disease=Disease | |?Treats disease=Disease | ||
|?Has Dose=Dose | |?Has Dose=Dose | ||
|?Has Context=Context | |?Has Context=Context | ||
|format=table | |format=table | ||
|limit=50 | |limit=50 | ||
|mainlabel=- | |mainlabel=- | ||
|headers=show | |headers=show | ||
|sort=Treats disease | |sort=Treats disease | ||
}} | }} | ||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
===Indications by Disease=== | ===Indications by Disease=== | ||
{{#ask: [[Has DrugName::Praziquantel]] [[Has Population::Pediatric]] | {{#ask: [[Has DrugName::Praziquantel]] [[Has Population::Pediatric]] | ||
|?Treats disease=Disease | |?Treats disease=Disease | ||
|?Has Dose=Dose | |?Has Dose=Dose | ||
|?Has Context=Context | |?Has Context=Context | ||
|format=table | |format=table | ||
|limit=50 | |limit=50 | ||
|mainlabel=- | |mainlabel=- | ||
|headers=show | |headers=show | ||
|sort=Treats disease | |sort=Treats disease | ||
}} | }} | ||
Latest revision as of 10:18, 22 March 2026
Administration
- Type: Antiparasitic, anthelmintic[1]
- Dosage Forms: 600
- Routes of Administration: Oral
- Common Trade Names: Biltricide
Adult Dosing
- Schistosomiasis: 20mg/kg PO tid x1 day
- Separate doses by 4-6h
- Give with food
- Do not crush/chew
- Liver flukes: 25mg/kg PO tid x1 day
- Separate doses by 4-6h
- Cysticercosis: 50mg/kg/day PO divided q8h x14 days
- Off label use
- Tapeworms: 5-25mg/kg PO x1
- Off label use
Indications by Disease
Pediatric Dosing
Indications by Disease
Special Populations
- Pregnancy Risk Factor B
Renal Dosing
- No renal dosing defined
Hepatic Dosing
- Caution advised with Child-Pugh Class B or C
Contraindications
- Allergy to class/drug
- ocular schistosomiasis
- ocular cysticercosis
- CNS lesions
- seizure history
Adverse Reactions
Serious
- Generalized hypersensitivity reaction
- polyserositis
- arrhythmias
- bradycardia
- ventricular fibrillation
- AV block
- diarrhea, bloody
- seizures
- Jarisch-Herxheimer reaction
Common
- malaise
- headache
- dizziness
- abdominal pain/nausea and vomiting
Pharmacology
- Half-life: 1-1.5hr
- Metabolism: CYP450
- Excretion: Urine
Mechanism of Action
- Increases cell membrane permeability
Comments
See Also
References
<Epocrates, UpToDate>
- ↑ Cioli D, et al. Schistosomiasis control: praziquantel forever? Mol Biochem Parasitol. 2014;195(1):23-29. PMID 24955523