Trazodone toxicity: Difference between revisions
m (Rossdonaldson1 moved page Trazodone Toxicity to Trazodone toxicity) |
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==Background== | ==Background== | ||
* | *[[Trazodone]] is extremely safe in overdose as long as there are no coingestants | ||
*Has serotonergic and | *Has serotonergic and α blocking effects | ||
==Clinical Features== | ==Clinical Features== | ||
*[[CNS Depression|CNS depression]] | |||
**Most common symptom | |||
**Rarely produces [[coma]] or [[seizures]] when it is the only drug ingested | |||
*[[Respiratory distress|Respiratory depression]] | |||
**Fairly common (but only with coingestants) | |||
*Orthostatic [[hypotension]] | |||
*[[QT prolongation]] | |||
== | ==Differential Diagnosis== | ||
{{Sedatve/hypnotic toxicity types}} | |||
==Evaluation== | |||
*Clinical diagnosis, assess for alternate etiologies | |||
==Management== | |||
*Supportive care | |||
*[[Activated charcoal]] and [[gastric lavage]] are not indicated | |||
*[[QT prolongation]] | |||
**Treat [[torsades]] in usual manner | |||
*Hypotension | |||
**[[IVF]] | |||
**[[Norepinephrine]] | |||
***[[Dopamine]] is contraindicated | |||
==Disposition== | ==Disposition== | ||
*Consider discharge for | *Consider discharge for patients who remain asymptomatic for at least 6 hours | ||
== | ==See Also== | ||
[[Category: | ==References== | ||
<references/> | |||
[[Category:Toxicology]] | |||
Latest revision as of 01:23, 14 September 2019
Background
- Trazodone is extremely safe in overdose as long as there are no coingestants
- Has serotonergic and α blocking effects
Clinical Features
- CNS depression
- Respiratory depression
- Fairly common (but only with coingestants)
- Orthostatic hypotension
- QT prolongation
Differential Diagnosis
Sedative/hypnotic toxicity
- Absinthe
- Barbiturates
- Benzodiazepines
- Chloral hydrate
- Gamma hydroxybutyrate (GHB)
- Baclofen toxicity
- Opioids
- Toxic alcohols
- Xylazine toxicity
Evaluation
- Clinical diagnosis, assess for alternate etiologies
Management
- Supportive care
- Activated charcoal and gastric lavage are not indicated
- QT prolongation
- Treat torsades in usual manner
- Hypotension
- IVF
- Norepinephrine
- Dopamine is contraindicated
Disposition
- Consider discharge for patients who remain asymptomatic for at least 6 hours