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| ==Background==
| | #REDIRECT[[Kaposi's sarcoma]] |
| *Angioproliferative disorder caused by HHV-8
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| *Divided into four types based on clinical circumstance
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| **Classic - typically presents in middle or old age
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| **Endemic - endemic in sub-Saharan Africa
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| **Iatrogenic - associated with immunosuppressive therapy
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| **AIDS-associated
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| ==Clinical Features==
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| *Skin Lesions
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| **Purplish, reddish blue, or brown macules, plaques, and nodules on the skin
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| **Ranging from very small to several cm in diameter
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| **May rapidly evolve and disseminate or remain unchanged over time
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| *Extracutaneous Manifestations
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| **Involvement of the mouth and GI tract
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| **Often asymptomatic but may cause bleeding or diarrhea
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| *Chronic, indolent course rarely influencing survival
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| ==Differential Diagnosis==
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| *Peripheral vascular disease
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| *Bacillary angiomatosis
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| *Angiosarcoma
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| *Hemangioma
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| ==Diagnosis==
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| *Biopsy is required for definitive diagnosis
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| *PCR of skin sample for HHV-8
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| ==Management==
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| *Primary goals of treatment: palliation, alleviating lymphedema, improving function, decreasing the size of cutaneous or visceral lesions, and delaying or preventing disease progression
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| *Surgery may be considered for singular lesions
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| *Radiation is effective though controversial
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| *Cryotherapy for local control, though effect is largely cosmetic
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| ==Disposition==
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| *Follow up for outpatient treatment
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| ==See Also==
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| ==External Links==
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| ==References==
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| <UpToDate>
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