Praziquantel: Difference between revisions
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==Administration== | ==Administration== | ||
*Type: | *Type: [[Antiparasitic]], anthelmintic<ref>Cioli D, et al. Schistosomiasis control: praziquantel forever? Mol Biochem Parasitol. 2014;195(1):23-29. PMID 24955523</ref> | ||
*Dosage Forms: 600 | *Dosage Forms: 600 | ||
*Routes of Administration: Oral | *Routes of Administration: Oral | ||
| Line 6: | Line 6: | ||
==Adult Dosing== | ==Adult Dosing== | ||
*Schistosomiasis: | *Schistosomiasis: 20mg/kg PO tid x1 day | ||
**Separate doses by 4-6h | **Separate doses by 4-6h | ||
**Give | **Give with food | ||
**Do not crush/chew | **Do not crush/chew | ||
*Liver flukes: | *Liver flukes: 25mg/kg PO tid x1 day | ||
**Separate doses by 4-6h | **Separate doses by 4-6h | ||
*Cysticercosis: | *Cysticercosis: 50mg/kg/day PO divided q8h x14 days | ||
**Off label use | **Off label use | ||
*Tapeworms: 5- | *Tapeworms: 5-25mg/kg PO x1 | ||
**Off label use | **Off label use | ||
===Indications by Disease=== | |||
{{#ask: [[Has DrugName::Praziquantel]] [[Has Population::Adult]] | |||
|?Treats disease=Disease | |||
|?Has Dose=Dose | |||
|?Has Context=Context | |||
|format=table | |||
|limit=50 | |||
|mainlabel=- | |||
|headers=show | |||
|sort=Treats disease | |||
}} | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
===Indications by Disease=== | |||
{{#ask: [[Has DrugName::Praziquantel]] [[Has Population::Pediatric]] | |||
|?Treats disease=Disease | |||
|?Has Dose=Dose | |||
|?Has Context=Context | |||
|format=table | |||
|limit=50 | |||
|mainlabel=- | |||
|headers=show | |||
|sort=Treats disease | |||
}} | |||
==Special Populations== | ==Special Populations== | ||
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*ocular cysticercosis | *ocular cysticercosis | ||
*CNS lesions | *CNS lesions | ||
*seizure | *seizure history | ||
==Adverse Reactions== | ==Adverse Reactions== | ||
| Line 58: | Line 74: | ||
*diarrhea, bloody | *diarrhea, bloody | ||
*seizures | *seizures | ||
*Jarisch-Herxheimer | *Jarisch-Herxheimer reaction | ||
===Common=== | ===Common=== | ||
*malaise | *malaise | ||
*headache | *headache | ||
*dizziness | *dizziness | ||
*abdominal pain/ | *abdominal pain/nausea and vomiting | ||
==Pharmacology== | ==Pharmacology== | ||
| Line 76: | Line 92: | ||
==See Also== | ==See Also== | ||
*[[Schistosomiasis]] | |||
==References== | ==References== | ||
<Epocrates, UpToDate> | <Epocrates, UpToDate> | ||
[[Category: | [[Category:Pharmacology]] [[Category:ID]] | ||
Latest revision as of 10:18, 22 March 2026
Administration
- Type: Antiparasitic, anthelmintic[1]
- Dosage Forms: 600
- Routes of Administration: Oral
- Common Trade Names: Biltricide
Adult Dosing
- Schistosomiasis: 20mg/kg PO tid x1 day
- Separate doses by 4-6h
- Give with food
- Do not crush/chew
- Liver flukes: 25mg/kg PO tid x1 day
- Separate doses by 4-6h
- Cysticercosis: 50mg/kg/day PO divided q8h x14 days
- Off label use
- Tapeworms: 5-25mg/kg PO x1
- Off label use
Indications by Disease
Pediatric Dosing
Indications by Disease
Special Populations
- Pregnancy Risk Factor B
Renal Dosing
- No renal dosing defined
Hepatic Dosing
- Caution advised with Child-Pugh Class B or C
Contraindications
- Allergy to class/drug
- ocular schistosomiasis
- ocular cysticercosis
- CNS lesions
- seizure history
Adverse Reactions
Serious
- Generalized hypersensitivity reaction
- polyserositis
- arrhythmias
- bradycardia
- ventricular fibrillation
- AV block
- diarrhea, bloody
- seizures
- Jarisch-Herxheimer reaction
Common
- malaise
- headache
- dizziness
- abdominal pain/nausea and vomiting
Pharmacology
- Half-life: 1-1.5hr
- Metabolism: CYP450
- Excretion: Urine
Mechanism of Action
- Increases cell membrane permeability
Comments
See Also
References
<Epocrates, UpToDate>
- ↑ Cioli D, et al. Schistosomiasis control: praziquantel forever? Mol Biochem Parasitol. 2014;195(1):23-29. PMID 24955523