Barbiturates: Difference between revisions

Latest revision as of 20:56, 20 February 2021

Are sedative/hypnotics used mainly for anesthesia and epilepsy
Increase the duration of GABA-A channel opening (as opposed to benzodiazepines, which increase frequency of channel opening)

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+==Background==
+*Are [[Sedative/hypnotic toxicity|sedative/hypnotics]] used mainly for anesthesia and epilepsy
+*Increase the duration of GABA-A channel opening (as opposed to [[benzodiazepines]], which increase frequency of channel opening)
 ==Types==
-*[[allobarbital]]
+{| {{table}}
-*[[amobarbital]]
+| align="center" style="background:#f0f0f0;"|'''Drug'''
-*[[aprobarbital]]
+| align="center" style="background:#f0f0f0;"|'''Half-life (h)'''
-*[[alphenal]]
+| align="center" style="background:#f0f0f0;"|'''Duration of Effect (h)'''
-*[[barbital]]
+| align="center" style="background:#f0f0f0;"|'''Hypnotic Dose (mg)'''
-*[[brallobarbital]]
+| align="center" style="background:#f0f0f0;"|'''Minimum Toxic level (mg/L)'''
-*[[pentobarbital]]
+|-
-*[[phenobarbital]]
+| '''Ultra–short-acting'''||||||||
-*[[secobarbital]]
+|-
+| [[Methohexital]]||3-5||< 0.5||50-120||>5
+|-
+| [[Thiopental]]||8-10||< 0.5||50-75||>5
+|-
+| '''Short-acting'''||||||||
+|-
+| [[Secobarbital]]||15-40||>3-4||100-200||>10
+|-
+| '''Intermediate-acting'''||||||||
+|-
+| [[Amobarbital]]||10-40||>4-6||65-200||>10
+|-
+| [[Butabarbital]]||35-50||>4-6||100-200||>10
+|-
+| '''Long-acting'''||||||||
+|-
+| [[Mephobarbital]]||10-70||>6-12||50-100||>30
+|-
+| [[Phenobarbital]]||80-120||>6-12||100-320||>30
+|}
 ==See Also==