Hirudins: Difference between revisions
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==Background== | ==Background== | ||
*Direct thrombin inhibitors | *Direct thrombin inhibitors | ||
** | |||
* | ==Drugs== | ||
*Hirudin | |||
*Lepirudin | |||
*[[Argatroban]] | |||
==Indications== | ==Indications== | ||
*[[HIT]] | |||
*[[Unstable angina]]/[[NSTEMI]]/PCI | |||
==Complications== | ==Complications== | ||
*Bleeding | |||
**Majority of bleeding events occur at invasive sites | |||
**No antidote available | |||
**Minor bleeding | |||
***Stop infusion | |||
**Major bleeding | |||
***Give [[FFP]] or PCC | |||
== | ==Pharmacology== | ||
*Half-life is ~2hr | |||
[[Category: | ==References== | ||
<references/> | |||
[[Category:Pharmacology]] | |||
[[Category:Heme/Onc]] | [[Category:Heme/Onc]] | ||
Latest revision as of 20:22, 22 September 2019
Background
- Direct thrombin inhibitors
Drugs
- Hirudin
- Lepirudin
- Argatroban
Indications
- HIT
- Unstable angina/NSTEMI/PCI
Complications
- Bleeding
- Majority of bleeding events occur at invasive sites
- No antidote available
- Minor bleeding
- Stop infusion
- Major bleeding
- Give FFP or PCC
Pharmacology
- Half-life is ~2hr