Template:HSV-1 antiviral treatment: Difference between revisions

Latest revision as of 22:28, 20 March 2026

Anti-viral Treatment

Normal Host

Options:
- Acyclovir
  - Acyclovir 400 mg PO 5x/day (q4hrs while awake) x 5 days OR
  - Acyclovir 40-80mg/kg PO divided in 3-4 doses for 5-7 days OR
  - Can also be used as topical cream 5x per day
- Famciclovir 500mg PO BID x 7 days OR
- Valacyclovir 2g PO q12h x 1 day

Immunocompromised

Options:
- Acyclovir
  - Acyclovir 5 mg/kg IV q8h x 7 days OR
  - Acyclovir 400mg PO 5x/day x 14-21 days
- Famciclovir 500mg PO BID x 7 days OR
- Valacyclovir 500mg PO BID x 5-10 days

@@ Line 1: / Line 1: @@
 ===Anti-viral Treatment===
-''Treatment does not affect dormant virus in nerve ganglions → recurrent disease remains possible''
+====Normal Host====
-'''Normal Host'''
 *Options:
-**[[Acyclovir]] 40-80mg/kg PO divided in 3-4 doses for 5-7 days
+**[[Acyclovir]]
-***Can also be used as a cream or oral suspension (swish and swallow)<ref name="Mohan">Mohan RPS, Verma S, Singh U, Agarwal N. Acute primary herpetic gingivostomatitis. BMJ Case Reports. 2013;2013:bcr2013200074. doi:10.1136/bcr-2013-200074.</ref>
+***{{AntibioticDose|drug=Acyclovir|dose=400 mg PO 5x/day (q4hrs while awake) x 5 days|context=Normal host|population=Adult}} OR
-**[[Valacyclovir]] (significantly higher bioavailability than acyclovir)
+***{{AntibioticDose|drug=Acyclovir|dose=40-80mg/kg PO divided in 3-4 doses for 5-7 days|context=Normal host|population=Pediatric}} OR
-**[[Famciclovir]]
+***Can also be used as topical cream 5x per day
+**{{AntibioticDose|drug=Famciclovir|dose=500mg PO BID x 7 days|context=Normal host|population=Adult}} OR
+**{{AntibioticDose|drug=Valacyclovir|dose=2g PO q12h x 1 day|context=Normal host|population=Adult}}
-'''Immunocompromised'''
+====Immunocompromised====
 *Options:
 **[[Acyclovir]]
-***5 mg/kg IV (over 1 hours) q8h x 7 days, OR
+***{{AntibioticDose|drug=Acyclovir|dose=5 mg/kg IV q8h x 7 days|context=Immunocompromised|population=Adult}} OR
-***400mg PO 5x/day x 14-21 days
+***{{AntibioticDose|drug=Acyclovir|dose=400mg PO 5x/day x 14-21 days|context=Immunocompromised (oral)|population=Adult}}
-**[[Famciclovir]] 500mg PO BID x 7 days, OR
+**{{AntibioticDose|drug=Famciclovir|dose=500mg PO BID x 7 days|context=Immunocompromised|population=Adult}} OR
-**[[Valacyclovir]] 500mg PO BID x 5-10 days
+**{{AntibioticDose|drug=Valacyclovir|dose=500mg PO BID x 5-10 days|context=Immunocompromised|population=Adult}}