Aztreonam

General

• Type: Monobactam
• Dosage forms: IM; IV
• Common Trade Names: Azactam

Other

• Antimicrobial activity more closely resembles AG's (only active against gram -)
  • Enterobacter, pseudomonas, H. influenzae, gonococci
  • Little allergic cross-reactivity with B-lactam antibiotics

Adult Dosing

General (Moderate Severe)

• 1-2g IM/IV q8-12h
• Max: 8g/day

General (Severe)

• 2g IM/IV q6-8h
• Max: 8g/day

Pediatric Dosing

General (Neonates)

• <7 days old
  • <2000g
    • 60 mg/kg/day IV divided q12h
    • First ED Dose: 30 mg/kg x 1
  • >2000g
    • 90 mg/kg/day IV divided q8
    • First ED Dose: 30 mg/kg x 1
• 7 days - 1 month
  • <1200g
    • 60 mg/kg/day IV divided q12h
    • First ED Dose: 30 mg/kg x 1
  • 1200-2000g
    • 90 mg/kg/day IV divided q8
    • First ED Dose: 30 mg/kg x 1
  • >2000g
    • 120 mg/kg/day IV divided q6
    • First ED Dose: 30 mg/kg x 1

General (1 Month - 9 Months)

• General
  • 90-120 mg/kg/day IV divided q6-8h
  • First ED Dose: 40 mg/kg x 1
• Respiratory Infections in Cystic Fibrosis
  • 200mg/kg/day IV divided q6h
  • First ED Dose: 40 mg/kg x 1
  • Max: 8g/day

General >9 Months)

• 90-120 mg/kg/day IV divided q6-8
• First ED Dose: 40 mg/kg x 1

Contraindications

• Allergy to class/drug

Pharmacology

• Half-life:
• Metabolism:
• Excretion:
• Mechanism of Action:

Pregnancy/Lactation

• Pregnancy:
• Lactation:

See Also

• Antibiotics (Main)