Cephalexin: Difference between revisions
No edit summary |
|||
| Line 39: | Line 39: | ||
*25-50 mg/kg/day PO divided q12h | *25-50 mg/kg/day PO divided q12h | ||
*Max: 500mg/dose | *Max: 500mg/dose | ||
==Special Populations== | |||
*Pregnancy: B | |||
*Lactation: Safe | |||
*Renal | |||
**Adult | |||
***CrCl 50-90: give q6-8h | |||
***CrCl 10-50: give q8-12h | |||
***CrCl <10: give q12-24h | |||
***Hemodialysis: give dose after dialysis, no supplement | |||
***Peritoneal dialysis: no supplement | |||
**Pediatric | |||
***CrCl 30-50: give q8h | |||
***CrCl 10-29: give q12h | |||
***CrCl <10: give q24h | |||
***Hemodialysis: give dose after dialysis, no supplement | |||
***Peritoneal dialysis: no supplement | |||
*Hepatic (Adult & Pediatric) | |||
**Not defined | |||
==Contraindications== | ==Contraindications== | ||
| Line 76: | Line 95: | ||
*Mechanism of Action: | *Mechanism of Action: | ||
**Bactericidal, inhibits cell wall | **Bactericidal, inhibits cell wall | ||
==See Also== | ==See Also== | ||
Revision as of 22:20, 27 February 2014
General
- Type: 1st generation cephalosporin
- Dosage forms
- Tabs: 250mg, 500mg, 750mg
- Liquid: 125mg/5mL; 250mg/5mL
- Common Trade Names: Keflex
Adult Dosing
General
- 250-500mg PO q6h
- Max: 4g/day
Strep Pharyngitis
- 500mg PO q12h x 10 days
Uncomplicated UTI
- 500mg PO q12h x 7-14 days
Cellulitis and Other Skin Infections
- 500mg PO q12h
Pediatric Dosing
General
- 25-50 mg/kg/day PO divided q6-12h
- Max: 500mg/dose
Otitis Media
- 75-100 mg/kg/day PO divided q12h x 10 days
- Max: 4,000 mg/24h
Community Acquired Pneumonia (>3 Months)
- 75-100 mg/kg/day PO divided q12h x 10 days
Streptococcal Pharyngitis (>1 Year)
- 40 mg/kg/day PO divided q12h x 10 days
- Max: 500mg/dose
Skin Infections
- 25-50 mg/kg/day PO divided q12h
- Max: 500mg/dose
Special Populations
- Pregnancy: B
- Lactation: Safe
- Renal
- Adult
- CrCl 50-90: give q6-8h
- CrCl 10-50: give q8-12h
- CrCl <10: give q12-24h
- Hemodialysis: give dose after dialysis, no supplement
- Peritoneal dialysis: no supplement
- Pediatric
- CrCl 30-50: give q8h
- CrCl 10-29: give q12h
- CrCl <10: give q24h
- Hemodialysis: give dose after dialysis, no supplement
- Peritoneal dialysis: no supplement
- Adult
- Hepatic (Adult & Pediatric)
- Not defined
Contraindications
- Allergy to class/drug
- See also Cephalosporin Cross-reactivity
- Caution advised with contraceptives
Adverse Drug Reactions
Serious
- Anaphylaxis
- Angioedema
- Erythema Multiforme
- Stevens-Johnson Syndrome
- Toxic Epidermal Necrolysis
- Clostridium difficile
- Neutropenia
- Thrombocytopenia
- Hemolytic anemia
- Hemorrhage
- Hepatitis
- Cholestatic jaundice
- Seizures
Common
Pharmacology
- Half-life: 1h (~20hr ESRD)
- Metabolism: Minimal
- Excretion: Primarily urine (>90% unchanged)
- Mechanism of Action:
- Bactericidal, inhibits cell wall
See Also
Source
- Sanford 2010
- Epocrates