Ampicillin/Sulbactam: Difference between revisions
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==Pediatric Dosing (<40kg)==
==Pediatric Dosing (<40kg)==
'''Unasyn (ampicillin/sulbactam) is formulated at a 2:1 ratio (3g vial = 2g ampicillin + 1g sulbactam)'''
'''Unasyn (ampicillin/sulbactam) is formulated at a 2:1 ratio (3g vial = 2g ampicillin + 1g sulbactam)'''
Note: Dosage recommendations are expressed as mg of the ampicillin component.
 
===General<ref>Red Book, 2012</ref>===
===General<ref>Red Book, 2012</ref>===
*'''<40kg'''
**Mild-moderate
**Mild-moderate
***100-200mg ampicillin/kg/day IM/IV divided q6 hours
***100-200mg ampicillin/kg/day IM/IV divided q6 hours
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***Meningitis: 400mg ampicillin/kg/day
***Meningitis: 400mg ampicillin/kg/day
***Max: 2000mg  
***Max: 2000mg  
*'''>40kg'''
**1.5-3g IM/IV q6 hours
**Max: Unasyn 12 g/day


===[[Endocarditis]]===
===[[Endocarditis]]===
*'''<40kg'''
**200mg ampicillin/kg/day IM/IV divided q4-6 hours +/- [[gentamicin]] x 4-6 weeks
**200mg ampicillin/kg/day IM/IV divided q4-6 hours +/- [[gentamicin]] x 4-6 weeks
*'''>40kg'''
**3g IM/IV q6 hours +/- [[gentamicin]] x 4-6 weeks


===[[Meningitis]]<ref>Red Book, 2009</ref>===
===[[Meningitis]]<ref>Red Book, 2009</ref>===
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===[[SSTI]]===
===[[SSTI]]===
*'''<40kg'''
**200mg ampicillin/kg/day IM/IV divided q6 hours
**200mg ampicillin/kg/day IM/IV divided q6 hours


Revision as of 23:56, 17 April 2014

General

  • Type: Amino-Penicillins
  • Dosage Forms:
  • Common Trade Names: Unasyn

Adult Dosing

General

  • 1500-3000mg IV/IM q6 hours
  • Max: 12g/day

Bite (for Pasteurella multocida Coverage)

  • 1500-3000mg IM/IV q6 hours

Orbital Cellulitis

  • 3000mg IM/IV q6 hours

Diabetic Foot Osteomyelitis[1]

  • 3000mg IM/IV q6 hours

PID

Pneumonia

  • Aspiration or CAP
    • 1500-3000mg IM/IV q6 hours
  • Hospital-acquired: 3000mg IM/IV q6 hours

UTI, Pyelonephritis

  • 3000mg IM/IV q6 hours x 14 days

Pediatric Dosing (<40kg)

Unasyn (ampicillin/sulbactam) is formulated at a 2:1 ratio (3g vial = 2g ampicillin + 1g sulbactam)

General[2]

    • Mild-moderate
      • 100-200mg ampicillin/kg/day IM/IV divided q6 hours
      • Max: 1000mg ampicillin
    • Severe:
      • 200mg ampicillin/kg/day divided q6 hours
      • Meningitis: 400mg ampicillin/kg/day
      • Max: 2000mg

Endocarditis

    • 200mg ampicillin/kg/day IM/IV divided q4-6 hours +/- gentamicin x 4-6 weeks

Meningitis[3]

  • <40kg
    • 200-400mg ampicillin/kg/day IV divided q6 hours

SSTI

    • 200mg ampicillin/kg/day IM/IV divided q6 hours

Special Populations

  • Pregnancy:
  • Lactation:
  • Renal Dosing
    • Adult
    • Pediatric
  • Hepatic Dosing
    • Adult
    • Pediatric

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

Common

Pharmacology

  • Half-life:
  • Metabolism:
  • Excretion:
  • Mechanism of Action:

See Also

Source

  1. ↑ Lipsky, 2004
  2. ↑ Red Book, 2012
  3. ↑ Red Book, 2009
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