Griseofulvin: Difference between revisions
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==Comments== | ==Comments== | ||
==Indications by Disease== | |||
''The following table is automatically generated from disease/condition pages across WikEM.'' | |||
{{#ask:[[Has DrugName::Griseofulvin]] | |||
|?Treats disease=Disease | |||
|?Has Dose=Dose | |||
|?Has Context=Context | |||
|?Has Population=Population | |||
|format=table | |||
|headers=plain | |||
|mainlabel=- | |||
|sort=Treats disease | |||
|limit=50 | |||
}} | |||
==See Also== | ==See Also== | ||
*[[Antifungals]] | *[[Antifungals]] | ||
Latest revision as of 22:34, 20 March 2026
Administration
- Type: Antifungal
- Dosage Forms: Suspension 125mg/5ml; Tablet 125mg, 250mg, 500mg
- Routes of Administration: Oral
- Common Trade Names: Grifulvin V, Gris-PEG
Adult Dosing
- 250-1000mg PO daily
Pediatric Dosing
- 13.6-22.7kg: 125-250mg PO daily
- >22.7kg: 250-500mg PO daily
Special Populations
- Pregnancy Rating: X
- Lactation risk: Not recommended given potential for serious side effects.
- Renal dosing: none
- Hepatic dosing: none
Contraindications
- Allergy to class/drug
- Hepatocellular failure
- Porphyria
- Pregnancy
Adverse Reactions
Serious
- Acroparesthesia
Common
- Photosensitivity, rash, urticaria
- Nausea/vomiting, diarrhea
- Headache
Pharmacology
- Half-life: 9-22h
- Metabolism: Liver
- Excretion: Urine, feces, perspiration
Mechanism of Action
- Fungistatic, deposits into keratin precursor cells and inhibits fungal mitosis
Comments
Indications by Disease
The following table is automatically generated from disease/condition pages across WikEM.
| Disease | Dose | Context | Population |
|---|---|---|---|
| Tinea capitis | Microsize: 20-25 mg/kg/day (max 1000mg) x 6-12 weeks; Ultramicrosize: 10-15 mg/kg/day (max 750mg) x 6-12 weeks | First line | Pediatric |