Fournier gangrene: Difference between revisions
| Line 11: | Line 11: | ||
*Advanced age | *Advanced age | ||
*Para/Quadriplegic | *Para/Quadriplegic | ||
* | *Males>Females (10:1)<ref name="Shyam" />, (likely under-diagnosed in women<ref name="Concepts">Wróblewska M et al. Fournier's gangrene: current concepts. Pol J Microbiol. 2014;63(3):267-73.</ref>) | ||
==Clinical Features== | ==Clinical Features== | ||
Revision as of 05:43, 14 December 2015
Background
- Life-threatening polymicrobial necrotizing fasciitis of perineum, genitalia, or perianal area.
- Mostly bacteria lower GI system - B. fragilis and E. coli
- Obliterative endarteritis of subcutaneous arterioles leads to gangrene of overlying skin[1]
- Mortality - often cited as 20-40%, but up to 80% in some studies[2]
Risk Factors
- Diabetes mellitus (most common)
- Hypertension
- Alcoholism
- Advanced age
- Para/Quadriplegic
- Males>Females (10:1)[1], (likely under-diagnosed in women[2])
Clinical Features
- Initial event is usually local trauma or extension of a UTI or perianal infection[1]
- Gangrene develops over 2-7 days
- Marked pain, localized swelling, crepitus, ecchymosis to genital or perineal area.
- Fever
- Malodorous purulent drainage
- In late or severe cases, pt may present in septic shock
Differential Diagnosis
Testicular Diagnoses
- Scrotal cellulitis
- Epididymitis
- Fournier gangrene
- Hematocele
- Hydrocele
- Indirect inguinal hernia
- Inguinal lymph node (Lymphadenitis)
- Orchitis
- Scrotal abscess
- Spermatocele
- Tinea cruris
- Testicular rupture
- Testicular torsion
- Testicular trauma
- Testicular tumor
- Torsion of testicular appendage
- Varicocele
- Pyocele
- Testicular malignancy
- Scrotal wall hematoma
Diagnosis
Work-up
- CBC
- CMP
- CRP
- Lactate
- Type and Screen
- Wound Culture
- Blood Cultures
- CT Abdomen/pelvis (only if diagnosis unclear or if requested by surgery/urology)
Evaluation
- Clinical diagnosis, based on history and physical exam
Treatment
- Immediate surgery and urology consult for surgical debridement (gangrene can spread at rate of 2-3 cm/hr[1])
- Antibiotics - Must cover gram positive, gram negative, and anaerobes
- Vancomycin + (imipenem 1gm IV q24hr OR meropenem 500mg-1gm IV q8hr)
- Aggressive supportive care, including fluid resuscitation (and pressors, if indicated)
Disposition
- Admit to ICU