Scurvy: Difference between revisions
(Created page with "==Background== Scurvy is the nutritional deficiency of Vitamin C (Ascorbic acid). Vitamin C is typically foundin fruits and vegetables. Vitamin C is a cofactor for hydroxylat...") |
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**Corkscrew appearance of hair. | **Corkscrew appearance of hair. | ||
==Clinical Features== | ==Clinical Features== | ||
*Gingival bleeding | |||
*Easy bruising | |||
*Petechiae | |||
*Corkscrew hair | |||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
Revision as of 16:00, 11 January 2016
Background
Scurvy is the nutritional deficiency of Vitamin C (Ascorbic acid). Vitamin C is typically foundin fruits and vegetables. Vitamin C is a cofactor for hydroxylation of proline and lysine amino acids in procollagen molecules, which is required for cross-linking collagen's triple helix. Scurvy therefore leads to unstable collagen and collagen fragility. This leads to the following:
- leaking of vascular structures
- gingival bleeding
- petechiae
- easy bruising
- leaking of vascular structures
Vitamin C is also required for the disulfide bonding in hair. Deficiency will thus lead to the following:
- Corkscrew appearance of hair.
Clinical Features
- Gingival bleeding
- Easy bruising
- Petechiae
- Corkscrew hair