Hirudins: Difference between revisions
(Created page with "==Background== *Direct thrombin inhibitors **Examples: Hirudin, lepirudin, argatroban *Half-life is ~2hr ==Indications== #HIT #UA/NSTEMI/PCI ==Complications== #Bleeding ##Majori...") |
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==Background== | ==Background== | ||
*Direct thrombin inhibitors | *Direct thrombin inhibitors | ||
** | |||
* | ==Drugs== | ||
*Hirudin | |||
*Lepirudin | |||
*Argatroban | |||
==Indications== | ==Indications== | ||
*[[HIT]] | |||
*[[Unstable angina]]/[[NSTEMI]]/PCI | |||
==Complications== | ==Complications== | ||
*Bleeding | |||
**Majority of bleeding events occur at invasive sites | |||
**No antidote available | |||
**Minor bleeding | |||
***Stop infusion | |||
**Major bleeding | |||
***Give [[FFP]] or PCC | |||
==Pharmacology== | |||
*Half-life is ~2hr | |||
== | ==References== | ||
[[Category:Drugs]] | [[Category:Drugs]] | ||
[[Category:Heme/Onc]] | [[Category:Heme/Onc]] | ||
Revision as of 12:58, 24 May 2015
Background
- Direct thrombin inhibitors
Drugs
- Hirudin
- Lepirudin
- Argatroban
Indications
- HIT
- Unstable angina/NSTEMI/PCI
Complications
- Bleeding
- Majority of bleeding events occur at invasive sites
- No antidote available
- Minor bleeding
- Stop infusion
- Major bleeding
- Give FFP or PCC
Pharmacology
- Half-life is ~2hr