Oseltamivir: Difference between revisions
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*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: | *[[Drug Ratings in Pregnancy|Pregnancy Rating]]: | ||
*[[Lactation risk categories|Lactation risk]]: | *[[Lactation risk categories|Lactation risk]]: | ||
*High Risk for Complications and Recommended for Treatment per CDC: | |||
**Children < 2 yo | |||
**Adults > 65 yo | |||
**Chronic Pulmonary Disease including Asthma | |||
**Cardiovascular disease (excluding HTN only) | |||
**Renal, hepatic, hematological, and metabolic disorders (including sickle cell, diabetes) | |||
**Neurological and Neurodevelopmental disorders (brain disorders, spinal cord, peripheral nerve disorders, cerebreal palsy, epilepsy, stroke, MR, developmental delay, muscular dystrophy) | |||
**Immunosuppressed including on HAART | |||
**Pregnant or Postpartum (2 weeks after delivery) | |||
**<19 yo on long term aspirin | |||
**American Indians/Alaskan natives | |||
**Morbid Obesity (BMI >= 40) | |||
**Nursing home or chronic care facility residents. | |||
===Renal Dosing=== | ===Renal Dosing=== | ||
*Adult: | *Adult: | ||
Revision as of 05:19, 27 April 2016
Administration
- Type:
- Dosage Forms:
- Routes of Administration:
- Common Trade Names: Tamiflu
Adult Dosing
Influenza
- 75mg PO BID x 5 days
Pediatric Dosing
Influenza
- Age <1 year: 3mg/kg PO BID x 5 days
- <15kg: 30mg PO BID x 5 days
- 15-23kg: 45mg PO BID x 5 days
- 24-40kg: 60mg PO BID x5d
- Adult: 75mg PO BID x 5 days
Special Populations
- Pregnancy Rating:
- Lactation risk:
- High Risk for Complications and Recommended for Treatment per CDC:
- Children < 2 yo
- Adults > 65 yo
- Chronic Pulmonary Disease including Asthma
- Cardiovascular disease (excluding HTN only)
- Renal, hepatic, hematological, and metabolic disorders (including sickle cell, diabetes)
- Neurological and Neurodevelopmental disorders (brain disorders, spinal cord, peripheral nerve disorders, cerebreal palsy, epilepsy, stroke, MR, developmental delay, muscular dystrophy)
- Immunosuppressed including on HAART
- Pregnant or Postpartum (2 weeks after delivery)
- <19 yo on long term aspirin
- American Indians/Alaskan natives
- Morbid Obesity (BMI >= 40)
- Nursing home or chronic care facility residents.
Renal Dosing
- Adult:
- Pediatric:
Hepatic Dosing
- Adult:
- Pediatric:
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
Common
Pharmacology
- Half-life:
- Metabolism:
- Excretion:
Mechanism of Action
Comments
- Influenza
- Shortens duration of illness by 16.8 hrs while NNTH (number needed to harm) was 28 in regards to causing n/v, HA, and renal and psych syndromes[1]
- Greatest benefit if within 48hrs of symptom onset[2]
- However, may be beneficial up to 4-5 days, including in pregnant patients
- Early treatment of hospitalized pts can reduce death
See Also
References
- ↑ Jefferson T, et al. Oseltamivir for influenza in adults and children: systematic review of clinical study reports and summary of regulatory comments. BMJ. 2014; 348:g2545.
- ↑ CDC Guidelines. 2015-2016. http://www.cdc.gov/flu/professionals/antivirals/summary-clinicians.htm