Coagulopathy (main): Difference between revisions
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==Background== | |||
*Primary hemostasis: damage to endothelial basement membrane and formation of platelet plug | |||
*Secondary hemostasis: coagulation cascade | |||
[[File:Coagulation cascade.png|thumbnail|Coagulation cascade]] | |||
==Clinical Features== | |||
*Spontaneous bleeding | |||
*Bleeding out of proportion | |||
*Swollen joints | |||
*[[Epistaxis]] | |||
*Bleeding gums | |||
*Menometrorrhagia | |||
*Easy bruising/petechiae | |||
*Hematuria | |||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
{{Increased bleeding DDX}} | {{Increased bleeding DDX}} | ||
Revision as of 22:22, 26 November 2016
Background
- Primary hemostasis: damage to endothelial basement membrane and formation of platelet plug
- Secondary hemostasis: coagulation cascade
Clinical Features
- Spontaneous bleeding
- Bleeding out of proportion
- Swollen joints
- Epistaxis
- Bleeding gums
- Menometrorrhagia
- Easy bruising/petechiae
- Hematuria
Differential Diagnosis
Coagulopathy
Platelet Related
- Too few
- Nonfunctional
Factor Related
- Acquired (Drug Related)
- Warfarin (Coumadin)
- Unfractionated heparin
- Low molecular weight heparin (i.e. enoxaparin (Lovenox), dalteparin)
- Factor Xa Inhibitors (e.g. rivaroxaban, apixaban, fondaparinux, edoxaban)
- Direct thrombin inhibitors (e.g. dabigatran, argatroban, bivalirudin)
- Illness induced
- Genetic
Increased Clotting
Managment
- Bleeding Treatments
- Procedures in patients with coagulopathies
- Anticoagulant reversal (known medications)
- Anti-platelet agent reversal