Methadone: Difference between revisions
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==Special Populations== | ==Special Populations== | ||
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: | *[[Drug Ratings in Pregnancy|Pregnancy Rating]]: Class C | ||
*[[Lactation risk categories|Lactation risk]]: | *[[Lactation risk categories|Lactation risk]]: infant risk minimal | ||
===Renal Dosing=== | ===Renal Dosing=== | ||
*Adult: lower initial starting dose | *Adult: lower initial starting dose | ||
===Hepatic Dosing=== | ===Hepatic Dosing=== | ||
*Adult: | *Adult: lower initial starting dose | ||
==Contraindications== | ==Contraindications== | ||
Revision as of 22:37, 10 July 2016
Administration
- Type: opioid
- Dosage Forms:
- Routes of Administration: oral, IM/subcutaneous
- Common Trade Names:
Adult Dosing
- varies widely due to patient variability in ADME, tolerance, indication
- Usual doses:
- Opioid use disorder, maintenance: 40-120mg/day
- Pain: initial dose 2.5mg TID for opioid naive
Pediatric Dosing
safety/efficacy not established in pediatric patients
- 0.1-0.2mg/kg q6h
Special Populations
- Pregnancy Rating: Class C
- Lactation risk: infant risk minimal
Renal Dosing
- Adult: lower initial starting dose
Hepatic Dosing
- Adult: lower initial starting dose
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
Common
Pharmacology
- Half-life:
- Metabolism:
- Excretion: