Tamsulosin: Difference between revisions
ClaireLewis (talk | contribs) (Created page with "==Administration== *Type: Alpha blocker *Dosage Forms: *Routes of Administration: oral *Common Trade Names: Flomax ==Adult Dosing== *0.4mg PO once daily ==Pediatric Dosing==...") |
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==Mechanism of Action== | ==Mechanism of Action== | ||
*Alpha-1A | *Alpha-1A antagonist→ smooth muscle relaxation in bladder neck, prostate, urethra→ increased urine flow rate | ||
==Comments== | ==Comments== | ||
Revision as of 19:06, 8 February 2017
Administration
- Type: Alpha blocker
- Dosage Forms:
- Routes of Administration: oral
- Common Trade Names: Flomax
Adult Dosing
- 0.4mg PO once daily
Pediatric Dosing
Safety/efficacy not established
Special Populations
- Pregnancy Rating: B
- Lactation risk: Infant risk cannot be ruled out
Renal Dosing
- Adult: No adjustment for CrCl >10
Hepatic Dosing
- Adult: No adjustment
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- Retinal detachment
- Priapism
Common
- Headache, dizziness, insomnia, somnolence
- Abnormal ejaculation
- Rhinitis
- Back pain
Pharmacology
- Half-life: 9-15h
- Metabolism: CYP3A4 and CYP2D6
- Excretion: Mostly renal
Mechanism of Action
- Alpha-1A antagonist→ smooth muscle relaxation in bladder neck, prostate, urethra→ increased urine flow rate