Dexmedetomidine: Difference between revisions
Ostermayer (talk | contribs) (Text replacement - "Category:Drugs" to "Category:Pharmacology") |
Neil.m.young (talk | contribs) (Text replacement - "alpha" to "α") |
||
| Line 37: | Line 37: | ||
*Metabolism: Hepatic | *Metabolism: Hepatic | ||
*Excretion: Renal | *Excretion: Renal | ||
*Mechanism of Action: Selective | *Mechanism of Action: Selective α-2 agonist | ||
==Comments== | ==Comments== | ||
Revision as of 01:13, 24 July 2017
General
- Type: Alpha-2 agonist; Sedative agents
- Dosage Forms:IV
- Common Trade Names: Precedex (US), Dexdor (European)
Adult Dosing
- ICU Sedation: 1 mcg/kg over 10 minutes followed by 0.2 to 0.7 mcg/kg/hr
- Procedural Sedation: 1 mcg/kg over 10 minutes followed by 0.6 mcg/hr titrated to effect, generally 0.2 to 1 mcg/kg/hr
Pediatric Dosing
Special Populations
- Pregnancy Rating: C
- Lactation: Unknown if excreted in milk. Exercise caution
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- Hypotension
- Bradycardia
- Apnea
Common
- Hypotension
- Bradycardia
- Dry mouth
Pharmacology
- Half-life: 2 hours
- Metabolism: Hepatic
- Excretion: Renal
- Mechanism of Action: Selective α-2 agonist
Comments
- Provides analgesia and anesthesia
- Hemodynamically neutral medication
- Provides sedation with maintenance of arousability, airway protection