Labetalol: Difference between revisions
Neil.m.young (talk | contribs) (Text replacement - "beta blocker" to "β-blocker") |
Neil.m.young (talk | contribs) (Text replacement - "α1 blocker" to "α<sub>1</sub>-blocker") |
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*Mechanism of Action: | *Mechanism of Action: | ||
**Class II - Nonselective β-blocker | **Class II - Nonselective β-blocker | ||
** | **α<sub>1</sub>-blocker | ||
*Onset of action = 2-5min (IV) | *Onset of action = 2-5min (IV) | ||
*Duration of action = 2-4hr (IV) | *Duration of action = 2-4hr (IV) | ||
Revision as of 23:13, 2 August 2017
General
- Type: Beta blockers
- Dosage Forms:
- Common Trade Names:
Adult Dosing
- Bolus dosing
- 20mg IV followed by 40-80mg q10min up to total of 300mg
- Infusion dosing
- 0.5-2mg/min
Pediatric Dosing
Special Populations
- Pregnancy Rating: C
- Lactation: Compatible with breastfeeding
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Indications
- hypertension in setting of myocardial ischemia
- hypertension in setting of neurologic injury
- hypertension in setting of preeclampsia/eclampsia
Contraindications
- Allergy to class/drug
Adverse Reactions
- Orthostatic hypotension
Pharmacology
- Half-life: 5-8hrs
- Metabolism: Hepatic via conjugation
- Excretion: Renal 55-60%
- Mechanism of Action:
- Class II - Nonselective β-blocker
- α1-blocker
- Onset of action = 2-5min (IV)
- Duration of action = 2-4hr (IV)